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Immunohistochemical study was performed on paraffin sections, including markers for oestrogen, progesterone and androgen receptors, keratin 5, HER2\/neu, epithelial growth factor receptor, p63 protein, P-cadherin, and Ki-67. Tubular (16 cases), mucinous (27) and papillary (9) types were all categorised as luminal-like A and B. The medullary (21) and metaplastic (10) types corresponded largely to the basal-like tumours (85.7% and 90%, respectively). Cases of the micropapillary type (8) were luminal A (3\/8), luminal B (4\/8) and HER2 overexpressing (1\/8), whereas the apocrine carcinomas (24) presented a heterogeneous profile. The proliferation rate (Ki-67) varied among the types, being the medullary carcinoma subtype with higher proliferation. Comparing the current data with those based on molecular studies, there was good agreement in the classification of the tubular, mucinous and papillary types. Only a partial concordance was achieved for the other types, which may be due to sampling, and to the relatively low frequency of such cases. The present work supports the clinical usage of immunohistochemistry as a surrogate to molecular classification of special types of BC.<\/jats:p>","DOI":"10.1136\/jclinpath-2012-200885","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T20:47:30Z","timestamp":1346705250000},"page":"1066-1071","source":"Crossref","is-referenced-by-count":14,"title":["Reappraisal of immunohistochemical profiling of special histological types of breast carcinomas: a study of 121 cases of eight different subtypes"],"prefix":"10.1136","volume":"65","author":[{"given":"C\u00e9sar Augusto","family":"Alvarenga","sequence":"first","affiliation":[{"name":"IPATIMUP: Institute of Molecular Pathology and Immunology of the University of Porto, University of Porto, Porto, Portugal"},{"name":"Instituto de Patologia de Campinas, Campinas, S\u00e3o Paulo, Brazil"}]},{"given":"Paula Itagyba","family":"Paravidino","sequence":"additional","affiliation":[{"name":"IPATIMUP: Institute of Molecular Pathology and Immunology of the University of Porto, University of Porto, Porto, Portugal"},{"name":"Instituto de Patologia de Campinas, Campinas, S\u00e3o Paulo, Brazil"}]},{"given":"Marcelo","family":"Alvarenga","sequence":"additional","affiliation":[{"name":"Instituto de Patologia de Campinas, Campinas, S\u00e3o Paulo, Brazil"}]},{"given":"Madalena","family":"Gomes","sequence":"additional","affiliation":[{"name":"IPATIMUP: Institute of Molecular Pathology and Immunology of the University of Porto, University of Porto, Porto, Portugal"}]},{"given":"Rozany","family":"Dufloth","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidade Estadual Paulista (UNESP), Botucatu, S\u00e3o Paulo, Brazil"}]},{"given":"Luiz Carlos","family":"Zeferino","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, State University of Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil"}]},{"given":"Jos\u00e9","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Laboratory of Investigative and Molecular Pathology, State University of Campinas Medical School (UNICAMP), Campinas, S\u00e3o Paulo, Brazil"},{"name":"Department of Pathology of the Hospital do Cancer A C Camargo, Funda\u00e7\u00e3o Antonio Prudente, Campinas, S\u00e3o Paulo, Brazil"}]},{"given":"Fernando C","family":"Schmitt","sequence":"additional","affiliation":[{"name":"IPATIMUP: Institute of Molecular Pathology and Immunology of the University of Porto, University of Porto, Porto, Portugal"},{"name":"Department of Pathology and Oncology, Medical Faculty, Porto University, Porto, Portugal"}]}],"member":"239","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"2025120518495621000_65.12.1066.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00118-7"},{"key":"2025120518495621000_65.12.1066.2","doi-asserted-by":"publisher","DOI":"10.1309\/J3QV9763DYPV338D"},{"key":"2025120518495621000_65.12.1066.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.166"},{"key":"2025120518495621000_65.12.1066.4","doi-asserted-by":"publisher","DOI":"10.1002\/path.2419"},{"key":"2025120518495621000_65.12.1066.5","doi-asserted-by":"publisher","DOI":"10.1002\/path.1691"},{"key":"2025120518495621000_65.12.1066.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2193"},{"key":"2025120518495621000_65.12.1066.7","unstructured":"Ellis P Schnitt SJ Sastre-Garau . 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