{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:14:08Z","timestamp":1765610048609,"version":"3.37.3"},"reference-count":27,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2020,7,22]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen molecular laboratories from seven different European countries compared 4\u2009weeks of national lockdown to a corresponding period in 2019, in terms of tissue and\/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6\/15), the decrease was &gt;25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jclinpath-2020-206957","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T21:15:51Z","timestamp":1596230151000},"page":"391-395","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe"],"prefix":"10.1136","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-9957","authenticated-orcid":false,"given":"Umberto","family":"Malapelle","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-0620","authenticated-orcid":false,"given":"Pasquale","family":"Pisapia","sequence":"additional","affiliation":[]},{"given":"Antonino","family":"Iaccarino","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-4804","authenticated-orcid":false,"given":"Massimo","family":"Barberis","sequence":"additional","affiliation":[]},{"given":"Claudio","family":"Bellevicine","sequence":"additional","affiliation":[]},{"given":"Hans","family":"Brunnstr\u00f6m","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0609-8817","authenticated-orcid":false,"given":"Dario","family":"de Biase","sequence":"additional","affiliation":[]},{"given":"Giovanna","family":"De Maglio","sequence":"additional","affiliation":[]},{"given":"Kajsa","family":"Ericson Lindquist","sequence":"additional","affiliation":[]},{"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[]},{"given":"Gabriella","family":"Fontanini","sequence":"additional","affiliation":[]},{"given":"Elisa","family":"Gruppioni","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0431-9353","authenticated-orcid":false,"given":"Paul","family":"Hofman","sequence":"additional","affiliation":[]},{"given":"Sabine","family":"Merkelbach-Bruse","sequence":"additional","affiliation":[]},{"given":"Miguel A","family":"Molina Vila","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-7420","authenticated-orcid":false,"given":"Ana\u00efs","family":"Pujals","sequence":"additional","affiliation":[]},{"given":"Ida","family":"Rapa","sequence":"additional","affiliation":[]},{"given":"Luisella","family":"Righi","sequence":"additional","affiliation":[]},{"given":"Rafael","family":"Rosell","sequence":"additional","affiliation":[]},{"given":"Oliver","family":"Schildgen","sequence":"additional","affiliation":[]},{"given":"Verena","family":"Schildgen","sequence":"additional","affiliation":[]},{"given":"Fernando C","family":"Schmitt","sequence":"additional","affiliation":[]},{"given":"Giovanni","family":"Tallini","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Vander Borght","sequence":"additional","affiliation":[]},{"given":"Elena","family":"Vigliar","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Volante","sequence":"additional","affiliation":[]},{"given":"Svenja","family":"Wagener-Ryczek","sequence":"additional","affiliation":[]},{"given":"Birgit","family":"Weynand","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-5805","authenticated-orcid":false,"given":"Giancarlo","family":"Troncone","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"2024053002111495000_74.6.391.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"2024053002111495000_74.6.391.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30185-9"},{"key":"2024053002111495000_74.6.391.3","unstructured":"World Health Organization . 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