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The team has established the clinical criteria for <jats:italic>CDH1<\/jats:italic> screening and results\u2019 interpretation, and created consensus guidelines regarding genetic counselling, breast surveillance and imaging techniques, clinicopathological findings, psychological and decisional support, as well as prophylactic surgery and plastic reconstruction. Based on a review of current evidence for the identification of HLBC cases\/families, <jats:italic>CDH1<\/jats:italic> genetic testing is recommended in patients fulfilling the following criteria: (A) bilateral LBC with or without family history of LBC, with age at onset &lt;50 years, and (B) unilateral LBC with family history of LBC, with age at onset &lt;45 years. In <jats:italic>CDH1<\/jats:italic> asymptomatic mutant carriers, breast surveillance with clinical examination, yearly mammography, contrast-enhanced breast MRI and breast ultrasonography (US) with 6-month interval between the US and the MRI should be implemented as a first approach. In selected cases with personal history, family history of LBC and <jats:italic>CDH1<\/jats:italic> mutations, prophylactic mastectomy could be discussed with an integrative group of clinical experts. Psychodecisional support also plays a pivotal role in the management of individuals with or without <jats:italic>CDH1<\/jats:italic> germline alterations. 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