{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:36:12Z","timestamp":1774352172035,"version":"3.50.1"},"reference-count":46,"publisher":"BMJ","issue":"e3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2023,2,9]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Endovascular therapy (EVT) is a highly effective stroke treatment, but it requires the administration of contrast media which puts patients at risk of acute kidney injury (AKI). AKI is associated with increased morbidity and mortality in cardiovascular patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PubMed, Scopus, ISI and the Cochrane Library were systematically searched for observational and experimental studies assessing the occurrence of AKI in adult acute stroke patients submitted to EVT. Two independent reviewers collected study data regarding study setting, period, source of data, and AKI definition and predictors, the outcomes of interest being AKI incidence and 90-day death or dependency (modified Rankin Scale score \u22653). These outcomes were pooled using random effect models, and heterogeneity was measured using the I<jats:sup>2<\/jats:sup> statistic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>22 studies were identified and included in the analysis, involving 32 034 patients. Pooled incidence of AKI was 7% (95% CI 5% to 10%), but heterogeneity was high across studies (I<jats:sup>2<\/jats:sup>=98%), and not accounted for by the definition of AKI used. The most frequently reported AKI predictors were impaired baseline renal function (5 studies) and diabetes (3 studies); 3 studies (2103 patients) reported data on death and 4 studies (2424 patients) reported data on dependency. Overall, AKI was associated with both outcomes, with ORs of 6.21 (95% CI 3.52 to 10.96) and 2.86 (95% CI 1.88 to 4.37), respectively. Heterogeneity was low for both analyses (I<jats:sup>2<\/jats:sup>=0%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>AKI affects 7% of acute stroke patients submitted to EVT and identifies a subgroup of patients for which treatment outcomes are suboptimal, with an increased risk of death and dependency.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jnis-2022-019955","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T13:20:35Z","timestamp":1676553635000},"page":"e468-e474","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Acute kidney injury after endovascular therapy in acute stroke patients: systematic review with meta-analysis"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3409-5314","authenticated-orcid":false,"given":"Marta","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Portugal"}]},{"given":"Ana","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Universidade de Aveiro, Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-0941","authenticated-orcid":false,"given":"Fl\u00e1via","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Universidade de Aveiro, Aveiro, Portugal"}]},{"given":"Pedro","family":"Barros","sequence":"additional","affiliation":[{"name":"Stroke Unit, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Porto, Portugal"},{"name":"Neurology, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Porto, Portugal"}]},{"given":"Lu\u00edsa","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Stroke Unit, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Manuel","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Cerebrovascular Interventional Neuroradiology Unit, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Porto, Portugal"}]},{"given":"Vera","family":"Afreixo","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Mathematics and Applications, University of Aveiro, Aveiro, Portugal"}]},{"given":"Tiago","family":"Greg\u00f3rio","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Portugal"},{"name":"Stroke Unit, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Porto, Portugal"},{"name":"MEDCIDS, Universidade do Porto Faculdade de Medicina, Porto, Portugal"}]}],"member":"239","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"2025092911120212000_15.e3.e468.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"2025092911120212000_15.e3.e468.2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319832140"},{"key":"2025092911120212000_15.e3.e468.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1805256"},{"key":"2025092911120212000_15.e3.e468.4","doi-asserted-by":"crossref","unstructured":"Jhou H , Chen P , Yang L , et al . 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