{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:37:05Z","timestamp":1773693425396,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["FP7-HEALTH-F2-2012-305549 \u2018Euro-TEAM\u2019"],"award-info":[{"award-number":["FP7-HEALTH-F2-2012-305549 \u2018Euro-TEAM\u2019"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001921","name":"Public Health Research Programme","doi-asserted-by":"publisher","award":["Birmingham Biomedical Research Centre programmeThe R4RA trial"],"award-info":[{"award-number":["Birmingham Biomedical Research Centre programmeThe R4RA trial"]}],"id":[{"id":"10.13039\/501100001921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["The STRAP trial"],"award-info":[{"award-number":["The STRAP trial"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["1854720298The STRAP trial"],"award-info":[{"award-number":["1854720298The STRAP trial"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R125-A3326R133-A3502"],"award-info":[{"award-number":["R125-A3326R133-A3502"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","award":["9-A541"],"award-info":[{"award-number":["9-A541"]}],"id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2018,9,22]]},"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We present a European multicenter study, comparing safety data and patient-reported outcomes (PRO) from patients undergoing synovial biopsy using ultrasound-guided needle biopsy (US-NB), ultrasound-guided portal and forceps (US-P&amp;F) or arthroscopic-guided (AG) procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe safety and PRO data on joint indices of pain, stiffness and swelling before and after biopsy, procedural discomfort, joint status compared with before biopsy and willingness to undergo a second biopsy for each technique and compare the three techniques. To evaluate the impact on PRO and safety data of corticosteroid therapy as part of the biopsy procedure and sequential biopsy procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were collected on the day of biopsy and 7\u201314 days postprocedure. Joint pain, swelling and stiffness indices were recorded as 0\u2013100 \u2009mm Visual Analogue Scale; qualitative outcome variables on five-point Likert scales. Groups were compared with linear regression, adjusting for disease activity, corticosteroid therapy and prebiopsy PRO value and accounting for repeated measurements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 524 synovial biopsy procedures were documented (402 US-NB, 65 US-P&amp;F and 57 AGSB). There were eight adverse events (1.5%) with no difference between biopsy methods (p=0.55). All PROs were improved 2 \u2009weeks postprocedure, and there were no differences in postbiopsy change in PROs between biopsy methods. Corticosteroid administration, whether intramuscular (n=62) or intra-articular (n=38), did not result in more adverse events (p=0.81) and was associated with reduction in postbiopsy swelling (p&lt;0.01). Sequential biopsy procedures (n=103 patients) did not result in more adverse events (p=0.61) or worsening in PRO data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Overall, our results do not suggest a significant difference in safety or patient tolerability between US-NB, US-P&amp;F and AGSB sampling. Further, corticosteroid therapy as part of the biopsy procedure and sequential biopsies is safe and well tolerated in patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2018-000799","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T08:17:41Z","timestamp":1540541861000},"page":"e000799","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe"],"prefix":"10.1136","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-5919","authenticated-orcid":false,"given":"S\u00f8ren Andreas","family":"Just","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Odense University Hospital, Odense, Denmark"}]},{"given":"Frances","family":"Humby","sequence":"additional","affiliation":[{"name":"Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK"}]},{"given":"Hanne","family":"Lindegaard","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Odense University Hospital, Odense, Denmark"}]},{"given":"Laurent","family":"Meric de Bellefon","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Saint-Pierre University Hospital, Brussels, Belgium"},{"name":"Rhumatologie, Cliniques Universitaires Saint-Luc, Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Bruxelles, Belgium"}]},{"given":"Patrick","family":"Durez","sequence":"additional","affiliation":[{"name":"Rhumatologie, Cliniques Universitaires Saint-Luc, Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Bruxelles, Belgium"}]},{"given":"Elsa","family":"Vieira-Sousa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Rheumatology Department, Hospital de Santa Maria, CHLN, Lisbon Academic Medical Centre, Lisbon, Portugal"}]},{"given":"Rui","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Rheumatology Department, Hospital de Santa Maria, CHLN, Lisbon Academic Medical Centre, Lisbon, Portugal"}]},{"given":"Maria","family":"Stoenoiu","sequence":"additional","affiliation":[{"name":"Rhumatologie, Cliniques Universitaires Saint-Luc, Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Bruxelles, Belgium"}]},{"given":"Jens","family":"Werlinrud","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Odense University Hospital, Odense, Denmark"}]},{"given":"Sofie","family":"Rosmark","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Odense University Hospital, Odense, Denmark"}]},{"given":"Pia Veldt","family":"Larsen","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark"}]},{"given":"Arthur","family":"Pratt","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine, Newcastle University, Newcastle, UK"},{"name":"Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, UK"}]},{"given":"Ernest","family":"Choy","sequence":"additional","affiliation":[{"name":"CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK"}]},{"given":"Nagui","family":"Gendi","sequence":"additional","affiliation":[{"name":"Basildon University Hospital, Basildon, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-5642","authenticated-orcid":false,"given":"Maya H","family":"Buch","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK"},{"name":"NIHR Leeds Musculoskeletal Biomedical Research Centre, Leeds, UK"}]},{"given":"Christopher J","family":"Edwards","sequence":"additional","affiliation":[{"name":"Southampton MSK Research Unit, NIHR Clinical Research Facility, University Hospital Southampton, Southampton, UK"}]},{"given":"Peter C","family":"Taylor","sequence":"additional","affiliation":[{"name":"Botnar Research Centre, NDORMS, Oxford University, Oxford, UK"}]},{"given":"Iain B","family":"McInnes","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK"}]},{"given":"Jo\u00e3o Eurico","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Medicina 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