{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:59:42Z","timestamp":1776214782293,"version":"3.50.1"},"reference-count":28,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2020,9,15]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec id=\"s1\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the determinants of impaired spinal and hip mobility in patients with early axial spondyloarthritis (axSpA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"s2\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Five-year longitudinal data from the DEvenir des Spondyloarthrites Indiff\u00e9renci\u00e9es R\u00e9centes (DESIR) cohort were analysed. Associations were investigated using generalised estimating equations, using Bath Ankylosing Spondylitis Metrology Index (BASMI) linear or each of the five components of BASMI as dependent variables, and clinical and demographic variables as independent variables in univariable models. Multivariable analyses were performed, adjusting for potential confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"s3\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Data from 644 patients and 5152 visits were analysed. Higher BASMI values were independently and positively associated with Ankylosing Spondylitis Disease Activity Score C reactive protein (ASDAS-CRP) (adjusted B (adjB)=0.21; 95% CI=0.15 to 0.28), MRI spinal inflammation score (adjB=0.11; 95% CI=0.04 to 0.19), enthesitis score (adjB=0.02; 95% CI=0.01 to 0.04) and age (adjB=0.02; 95% CI=0.01 to 0.03). All BASMI components were independently associated with ASDAS-CRP and MRI spinal inflammation, except for maximal intermalleolar distance (reflecting hip mobility), which was not associated with MRI spinal inflammation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"s4\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In early axSpA, spinal mobility impairment is independently determined by clinical disease activity, MRI spinal inflammation, enthesitis and age. The influence of spinal inflammation prevails in early axSpA, as opposed to spinal structural damage, which may become more relevant in later disease stages.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2020-001356","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T13:15:14Z","timestamp":1602767714000},"page":"e001356","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-4274","authenticated-orcid":false,"given":"Pedro D","family":"Carvalho","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Centro Hospitalar Universit\u00e1rio do Algarve, Faro, Portugal"},{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Algarve Biomedical Center, Faro, Portugal"}]},{"given":"Adeline","family":"Ruyssen-Witrand","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Toulouse, Toulouse, France"}]},{"given":"Joao","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Department of Rheumatology, Santa Maria Hospital - CHLN, Lisbon, Portugal"}]},{"given":"Ana","family":"Marreiros","sequence":"additional","affiliation":[{"name":"Algarve Biomedical Center, Faro, Portugal"},{"name":"Universidade do Algarve, Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-7972","authenticated-orcid":false,"given":"Pedro M","family":"Machado","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology and Department of Neuromuscular Diseases, University College London, London, UK"},{"name":"Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK"}]}],"member":"239","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"2025090313401382000_6.3.e001356.1","first-page":"951","article-title":"Selection of instruments in the core set for DC-ART, SMARD, physical therapy, and clinical record keeping in ankylosing spondylitis. progress report of the ASAS Working Group. 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