{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T06:20:03Z","timestamp":1774765203899,"version":"3.50.1"},"reference-count":44,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"unspecified","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2021,11,3]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare physical disability, mental health, fatigue and health-related quality of life (HRQoL) across juvenile idiopathic arthritis (JIA) categories in adulthood and between JIA and adult-onset rheumatic diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross-sectional analysis nested in a cohort of adult patients with JIA registered in the Rheumatic Diseases Portuguese Register (Reuma.pt). Physical disability (Health Assessment Questionnaire\u2014Disability Index), mental health symptoms (Hospital Anxiety and Depression Scale), fatigue (Functional Assessment of Chronic Illness Therapy\u2014Fatigue Scale (FACIT-F)) and HRQoL (EuroQol-5D (EQ5D) and Short Form (SF-36)) were compared across JIA categories. Patients with polyarticular JIA and enthesis-related arthritis (ERA) JIA were compared respectively to patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA), matched for gender and age, adjusted for disease duration and activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>585 adult patients with JIA were included. Comparison across JIA categories showed that persistent oligoarthritis and patients with ERA reported a higher score in EQ5D and SF-36 physical component when compared with other JIA categories.<\/jats:p>\n                  <jats:p>Polyarticular JIA reported less disability and fatigue than patients with RA (median Health Assessment Questionnaire of 0.25 vs 0.63; p&lt;0.001 and median FACIT-F score 42 vs 40 ; p=0.041). Polyarticular JIA had also better scores on EQ5D and all domains of SF-36, than patients with RA. Patients with ERA reported less depression and anxiety symptoms (0% vs 14.8%; p=0.003% and 9% vs 21.3%; p=0.002) and less fatigue symptoms (45 vs 41; p=0.01) than patients with SpA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Persistent oligoarticular JIA and ERA are the JIA categories in adulthood with better HRQoL. Overall, adult polyarticular and patients with ERA JIA have lower functional impairment and better quality-of-life than patients with RA and SpA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2021-001766","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T12:45:48Z","timestamp":1637757948000},"page":"e001766","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Health-related quality of life and disability in adults with juvenile idiopathic arthritis: comparison with adult-onset rheumatic diseases"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-8909","authenticated-orcid":false,"given":"Filipa","family":"Oliveira Ramos","sequence":"first","affiliation":[{"name":"Rheumatology Department and Pediatric Rheumatology Unit, Centro Hospitalar Universit\u00e1rio Lisboa Norte EPE, Lisboa, Portugal"},{"name":"Faculdade de Medicina, Universidade de Lisboa Instituto de Medicina Molecular, Lisboa, Portugal"}]},{"given":"Ana","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre for Chronic Diseases (CEDOC), CHRC Campus Nova Medical School, Lisboa, Portugal"}]},{"given":"Fernando","family":"Magalhaes Martins","sequence":"additional","affiliation":[{"name":"Portuguese Society of Rheumatology, Lisboa, Portugal"}]},{"given":"Ana Teresa","family":"Melo","sequence":"additional","affiliation":[{"name":"Rheumatology Department and Pediatric Rheumatology Unit, Centro Hospitalar Universit\u00e1rio Lisboa Norte EPE, Lisboa, Portugal"}]},{"given":"Francisca","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Young Adult and Pediatric Rheumatology Unit, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal"}]},{"given":"Luisa","family":"Brites","sequence":"additional","affiliation":[{"name":"Rheumatology, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Portugal"}]},{"given":"Soraia","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Rheumatology, Unidade Local de Saude do Alto Minho EPE, Viana do Castelo, Portugal"}]},{"given":"Ana Catarina","family":"Duarte","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Garcia de Orta EPE, Almada, Portugal"}]},{"given":"Carolina","family":"Furtado","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital do Divino Esp\u00edrito Santo, S\u00e3o Miguel, Ponta Delgada, Portugal"}]},{"given":"Ana Filipa","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Centre for Chronic Diseases (CEDOC), CHRC Campus Nova Medical School, Lisboa, Portugal"},{"name":"Rheumatology, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal"}]},{"given":"Gra\u00e7a","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Rheumatology, Centro Hospitalar Universit\u00e1rio do Algarve, Faro, Portugal"}]},{"given":"In\u00eas","family":"Cunha","sequence":"additional","affiliation":[{"name":"Rheumatology, Centro Hospitalar do Baixo Vouga EPE, Aveiro, Portugal"}]},{"given":"Ricardo","family":"Figueira","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Dr. N\u00e9lio Mendon\u00e7a, Funchal, Madeira, Portugal"}]},{"given":"Jose Antonio","family":"Melo Gomes","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Reumatologia, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-1365","authenticated-orcid":false,"given":"Maria Jose","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade de Lisboa Instituto de Medicina Molecular, Lisboa, Portugal"},{"name":"Rheumatology, Hospital Garcia de Orta EPE, Almada, Portugal"}]},{"given":"Joao Eurico","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Rheumatology Department and Pediatric Rheumatology Unit, Centro 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