{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:28:46Z","timestamp":1787228926994,"version":"build-2736575974"},"reference-count":22,"publisher":"Society for Industrial & Applied Mathematics (SIAM)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Multiscale Model. Simul."],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Here we present a single-cell-based model of cell-cell interactions in a growing yeast colony. We examine the influence of multiple factors on the colony morphology and switch to a foraging growth behavior. We find that the cell-growth inhibition by neighboring cells along with polar division growth patterns are the most significant factors driving the exploratory behavior of a colony.<\/jats:p>","DOI":"10.1137\/040603255","type":"journal-article","created":{"date-parts":[[2005,3,2]],"date-time":"2005-03-02T21:00:22Z","timestamp":1109797222000},"page":"346-361","source":"Crossref","is-referenced-by-count":19,"title":["An Explicit Spatial Model of Yeast Microcolony Growth"],"prefix":"10.1137","volume":"3","author":[{"given":"Henrik","family":"J\u00f6nsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Levchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"351","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E03-01-0042"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.15.1.365"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.240345197"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(02)00002-1"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81278-7"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00801-6"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(98)80117-3"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1038\/269145a0"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(77)90154-9"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"H. J\u00f6nsson, B. E. Shapiro, E. M. Meyerowitz, and E. Mjolsness,\n                      Signalling in multicellular models of plant development\n                      , in On Growth, Form and Computers, S. Kumar and P. Bentley, eds., Academic Press, London, 2003, pp. 156\u2013161.","DOI":"10.1016\/B978-012428765-5\/50041-4"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.5.9.1003"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03332.x"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.65.021903"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.7.2147"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-4-893"},{"key":"R16","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1242\/jcs.113.11.1923","volume":"113","author":"Palkova Z.","year":"2000","journal-title":"Cell Sci."},{"key":"R17","unstructured":"W. H. Press, S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery,\n                      Numerical Recipes in C: The Art of Scientific Computing\n                      , Cambridge University Press, New York, 1992."},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5505.878"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.79.313"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.18.9871"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)88862-9"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.2001.2293"}],"container-title":["Multiscale Modeling &amp; Simulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/epubs.siam.org\/doi\/pdf\/10.1137\/040603255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:03:43Z","timestamp":1787227423000},"score":1,"resource":{"primary":{"URL":"https:\/\/epubs.siam.org\/doi\/10.1137\/040603255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1137\/040603255"],"URL":"https:\/\/doi.org\/10.1137\/040603255","relation":{},"ISSN":["1540-3459","1540-3467"],"issn-type":[{"value":"1540-3459","type":"print"},{"value":"1540-3467","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}