{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:00:41Z","timestamp":1793750441987,"version":"4.6.1"},"reference-count":47,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Obesity is a public health problem that contributes to morbidity and mortality from diabetes, heart disease, stroke, and cancers. The purpose of this investigation was to analyse the link between obesity-induced oxidative stress, renal steatosis, and kidney dysfunction, as well as the protective effect of grape seed and skin extract. Rats were fed a standard diet or a high-fat diet for 6 weeks and were either treated or not treated with grape seed and skin extract. Fat-induced oxidative stress was evaluated in the kidney with a special emphasis on transition metals. High-fat diet induced triglyceride deposition and disturbances in kidney function parameters, which are linked to an oxidative stress status and depletion of copper from the kidney. Grape seed and skin extract abrogated almost all fat-induced kidney disturbances. Grape seed and skin extract exerted potential protection against fat-induced kidney lipotoxicity and should find potential application in other kidney-related diseases.<\/jats:p>","DOI":"10.1139\/apnm-2012-0416","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T17:28:47Z","timestamp":1357579727000},"page":"259-267","source":"Crossref","is-referenced-by-count":21,"title":["Grape seed and skin extract alleviates high-fat diet-induced renal lipotoxicity and prevents copper depletion in rat"],"prefix":"10.1139","volume":"38","author":[{"given":"Kamel","family":"Charradi","sequence":"first","affiliation":[{"name":"Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050 Hammam-Lif, Tunisie."},{"name":"Universit\u00e9 de Carthage, Facult\u00e9 des Sciences de Bizerte, 7021 Jarzouna, Tunisie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem","family":"Elkahoui","sequence":"additional","affiliation":[{"name":"Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050 Hammam-Lif, Tunisie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Karkouch","sequence":"additional","affiliation":[{"name":"Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050 Hammam-Lif, Tunisie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferid","family":"Limam","sequence":"additional","affiliation":[{"name":"Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050 Hammam-Lif, Tunisie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaith","family":"Hamdaoui","sequence":"additional","affiliation":[{"name":"Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050 Hammam-Lif, Tunisie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fethy Ben","family":"Hassine","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie, Polyclinique de la CNSS d'El Khadra, Avenue Zobeir Ibn El Awam 1003 Cit\u00e9 El Khadra Tunis, Tunisie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le Veronique","family":"El May","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche no. 01\/UR\/07-08, Faculty of Medicine of Tunis, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El May","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche no. 01\/UR\/07-08, Faculty of Medicine of Tunis, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezzedine","family":"Aouani","sequence":"additional","affiliation":[{"name":"Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050 Hammam-Lif, Tunisie."},{"name":"Universit\u00e9 de Carthage, Facult\u00e9 des Sciences de Bizerte, 7021 Jarzouna, Tunisie."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","unstructured":"Aebi, H. 1974. Methods of enzymatic analysis. 2nd ed. Chemia Weinheium. NewYork, N.Y., USA."},{"issue":"1","key":"refg2\/ref2","first-page":"3","volume":"27","author":"Bagchi D.","year":"2001","journal-title":"Drugs Exp. Clin. Res."},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:112:1:1"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-008-8289-2"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.4513"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900476"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32833aa4ac"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-010-9101-z"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0821-2"},{"issue":"3","key":"refg11\/ref11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.7326\/0003-4819-140-3-200402030-00007","volume":"140","author":"Chen J.","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl759"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr613"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1509-1"},{"issue":"1","key":"refg20\/ref20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/JAD-2009-1135","volume":"18","author":"Ferruzzi M.G.","year":"2009","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"refg21\/ref21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"Folch J.","year":"1957","journal-title":"J. Biol. Chem."},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(72)90094-2"},{"issue":"1","key":"refg24\/ref24","first-page":"87","volume":"86","author":"Kakinuma K.","year":"1979","journal-title":"J. Biochem."},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590041498.x"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.51"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2009.01221.x"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-9048-3"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00834.x"},{"key":"refg30\/ref30","first-page":"467","volume":"186","author":"Levine R.L.","year":"1990","journal-title":"Methods Enzymol."},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0630588100"},{"issue":"10","key":"refg32\/ref32","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","volume":"247","author":"Misra H.P.","year":"1972","journal-title":"J. Biol. Chem."},{"issue":"4","key":"refg33\/ref33","first-page":"356","volume":"43","author":"Mohanasundari M.","year":"2005","journal-title":"Indian J. Exp. Biol."},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(74)90455-0"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.03.049"},{"key":"refg36\/ref36","unstructured":"National Research Council. 1985. Guide for the care and the use of laboratory animals. National Institute of Health, Bethesda, Md., USA.20: 85."},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06307.x"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0616"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.601832"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200306000-00008"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900039"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-005-6837-x"},{"issue":"6","key":"refg44\/ref44","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/0009-8981(57)90063-3","volume":"2","author":"Stern J.","year":"1957","journal-title":"Clin. Chim. Acta"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.104057"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0590"},{"key":"refg48\/ref48","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04071206"},{"key":"refg49\/ref49","doi-asserted-by":"publisher","DOI":"10.3945\/an.110.000273"},{"key":"refg50\/ref50","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31823315f7"},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001834"},{"key":"refg52\/ref52","unstructured":"Worthington Biochemical Corporation. 1977. Worthington Enzyme Manual. Worthington Biochemical Corp., Freehold, N.J., USA. pp. 74\u201375."}],"container-title":["Applied Physiology, Nutrition, and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/apnm-2012-0416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/apnm-2012-0416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T13:21:06Z","timestamp":1644067266000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/apnm-2012-0416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1139\/apnm-2012-0416"],"URL":"https:\/\/doi.org\/10.1139\/apnm-2012-0416","relation":{},"ISSN":["1715-5312","1715-5320"],"issn-type":[{"value":"1715-5312","type":"print"},{"value":"1715-5320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}