{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:33:52Z","timestamp":1778513632661,"version":"3.51.4"},"reference-count":65,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p> The hypothesis that oral supplementation with the flavonoid rutin improves baroreflex sensitivity and vascular reactivity in hypertensive (2-kidney-1-clip (2K1C)) rats was tested. Sixty-four rats were divided in 4 groups: sham + saline; sham + rutin; 2K1C + saline, and 2K1C + rutin. Six weeks after 2K1C surgery, the animals were treated with saline or rutin (40 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) by gavage for 7 days. Baroreflex sensitivity test using phenylephrine (8 \u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>, iv) and sodium nitroprusside (25 \u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>, iv), vascular reactivity, and thiobarbituric acid reactive substances assay were performed. Baroreflex sensitivity in hypertensive rats was impaired and compared with sham (\u22122.77 \u00b1 0.15 vs. \u20131.53 \u00b1 0.27 beats\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mm Hg<jats:sup>\u22121<\/jats:sup>; n = 8; p &lt; 0.05). Oral supplementation with rutin restored baroreflex sensitivity in 2K1C rats (\u22122.40 \u00b1 0.24 vs. \u20132.77 \u00b1 0.15 beats\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mm Hg<jats:sup>\u22121<\/jats:sup>; n = 8; p &gt; 0.05). Besides, hypertensive rats have greater contraction to phenylephrine (129.49% \u00b1 4.46% vs. 99.50% \u00b1 11.36%; n = 8; p &lt; 0.05), which was restored by rutin (99.10% \u00b1 1.77% vs. 99.50% \u00b1 11.36%; n = 8; p &gt; 0.05). Furthermore, vasorelaxation to acetylcholine was diminished in hypertensive rats (96.42% \u00b1 2.80% vs. 119.35% \u00b1 5.60%; n = 8; p &lt; 0.05), which was also restored by rutin (117.55% \u00b1 6.94% vs. 119.35% \u00b1 5.60%; n = 8; p &gt; 0.05). Finally, oxidative stress was greater in hypertensive rats (1.54 \u00b1 0.12 vs. 0.53 \u00b1 0.12 nmol MDA\u00b7mL<jats:sup>\u22121<\/jats:sup>; n = 8; p &lt; 0.05) and rutin supplementation significantly decreased oxidative stress in those animals (0.70 \u00b1 0.13 vs. 1.54 \u00b1 0.12 nmol MDA\u00b7mL<jats:sup>\u22121<\/jats:sup>; n = 8; p &lt; 0.05). We concluded that oral supplementation with rutin restores impaired baroreflex sensitivity and vascular reactivity in hypertensive rats by decreasing oxidative stress. <\/jats:p>","DOI":"10.1139\/apnm-2013-0091","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T10:46:10Z","timestamp":1368096370000},"page":"1099-1106","source":"Crossref","is-referenced-by-count":36,"title":["Oral supplementation with the rutin improves cardiovagal baroreflex sensitivity and vascular reactivity in hypertensive rats"],"prefix":"10.1139","volume":"38","author":[{"given":"Le\u00f4nidas das Gra\u00e7as","family":"Mendes-Junior","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Biotechnology Center, Federal University of Paraiba, Jo\u00e3o Pessoa, PB 58051-900 Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Morais de Oliveira","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biotechnology Center, Federal University of Paraiba, Jo\u00e3o Pessoa, PB 58051-900 Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alynne dos Santos","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biotechnology Center, Federal University of Paraiba, Jo\u00e3o Pessoa, PB 58051-900 Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thyago Moreira de","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biotechnology Center, Federal University of Paraiba, Jo\u00e3o Pessoa, PB 58051-900 Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdir de Andrade","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biotechnology Center, Federal University of Paraiba, Jo\u00e3o Pessoa, PB 58051-900 Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.61.10.0014"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000182154.61862.52"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2005.04215.x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.07.025"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.12.007"},{"key":"refg65\/ref65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90375"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2011007500088"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.035022"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160564"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.062810"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/968123"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2012.01.009"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1161\/hy09t1.094005"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1080\/21551197.2012.698219"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.186"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1080\/10715760701732830"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.02.031"},{"key":"refg17\/ref17","first-page":"R1189","volume":"269","author":"DiBona G.F.","year":"1995","journal-title":"Am. 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