{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:40:43Z","timestamp":1762033243499,"version":"3.41.0"},"reference-count":56,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p> Pulses, including dried peas, are nutrient- and fibre-rich foods that improve glucose control in diabetic subjects compared with other fibre sources. We hypothesized feeding cooked pea seed coats to insulin-resistant rats would improve glucose tolerance by modifying gut responses to glucose and reducing stress on pancreatic islets. Glucose intolerance induced in male Sprague\u2013Dawley rats with high-fat diet (HFD; 10% cellulose as fibre) was followed by 3 weeks of HFD with fibre (10%) provided by cellulose, raw-pea seed coat (RP), or cooked-pea seed coat (CP). A fourth group consumed low-fat diet with 10% cellulose. Oral and intraperitoneal glucose tolerance tests (oGTT, ipGTT) were done. CP rats had 30% and 50% lower glucose and insulin responses in oGTT, respectively, compared with the HFD group (P &lt; 0.05) but ipGTT was not different. Plasma islet and incretin hormone concentrations were measured. \u03b1- and \u03b2-cell areas in the pancreas and density of K- and L-cells in jejunum and ileum were quantified. Jejunal expression of hexose transporters was measured. CP feeding increased fasting glucagon-like peptide 1 and glucose-stimulated gastric inhibitory polypeptide responses (P &lt; 0.05), but K- and L-cells densities were comparable to HFD, as was abundance of SGLT1 and GLUT2 mRNA. No significant difference in \u03b2-cell area between diet groups was observed. \u03b1-cell area was significantly smaller in CP compared with RP rats (P &lt; 0.05). Overall, our results demonstrate that CP feeding can reverse adverse effects of HFD on glucose homeostasis and is associated with enhanced incretin secretion and reduced \u03b1-cell abundance. <\/jats:p>","DOI":"10.1139\/apnm-2014-0380","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T22:35:21Z","timestamp":1416609321000},"page":"323-333","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Cooking enhances beneficial effects of pea seed coat consumption on glucose tolerance, incretin, and pancreatic hormones in high-fat-diet\u2013fed rats"],"prefix":"10.1139","volume":"40","author":[{"given":"Zohre","family":"Hashemi","sequence":"first","affiliation":[{"name":"Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn","family":"Ozga","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine B.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada."},{"name":"Department of Physiology, University of Alberta, Edmonton, AB T6G 2R3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.4161\/isl.2.6.13619"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.3305\/nh.2010.25.3.4459"},{"key":"refg4\/ref4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1499-2671(13)00192-5","volume":"37","author":"Canadian Diabetes Association Clinical Practice Guidelines Expert Committee","year":"2013","journal-title":"Can. 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