{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:11:49Z","timestamp":1751515909355,"version":"3.41.0"},"reference-count":22,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p> The purpose of this study was to examine the effect of oral contraceptive (OC) use on salivary secretory immunoglobulin A (SIgA) levels at rest and in response to an acute bout of moderate\u2013vigorous exercise during 2 phases of the 4-week OC cycle corresponding to different phases of the synthetic menstrual cycle. Ten healthy active females completed a cycling at 70% peak oxygen uptake for 45 min at 2 time points of an OC cycle: during the equivalent in time to the mid-follicular phase (day 8 \u00b1 2) and the mid-luteal phase (day 20 \u00b1 2). Timed unstimulated saliva samples were obtained before, immediately postexercise, and 1 h postexercise and analyzed for salivary SIgA. Salivary SIgA secretion rate was 26% (95% confidence limits (CI) 6\u201346) lower at postexercise compared with pre-exercise during the synthetic follicular phase (p = 0.019) but no differences were observed during the synthetic luteal trial. Saliva flow rate was 11% (95% CI, 8\u201330) lower at postexercise compared with pre-exercise (main effect for time; p = 0.025). In conclusion, the pattern of salivary SIgA secretion rate response to moderate\u2013vigorous exercise varies across the early and late phases of a monophasic OC cycle, with a transient reduction in salivary SIgA responses during the synthetic follicular phase. These findings indicate that monophasic OC use should be considered when assessing mucosal immune responses to acute exercise. <\/jats:p>","DOI":"10.1139\/apnm-2014-0468","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T15:06:24Z","timestamp":1428073584000},"page":"863-867","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Salivary SIgA responses to acute moderate\u2013vigorous exercise in monophasic oral contraceptive users"],"prefix":"10.1139","volume":"40","author":[{"given":"Harumi","family":"Hayashida","sequence":"first","affiliation":[{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."},{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola J.","family":"Dolan","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."},{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Hounsome","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."},{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawal","family":"Alajmi","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."},{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolette C.","family":"Bishop","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."},{"name":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"issue":"3","key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1123\/ijsnem.19.3.209","volume":"19","author":"Allgrove J.E.","year":"2009","journal-title":"Int. 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