{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:35:05Z","timestamp":1790393705792,"version":"4.1.0"},"reference-count":53,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p> Suboptimal vitamin B<jats:sub>12<\/jats:sub> (B12) status has been associated with an increased risk of congenital anomalies, preterm birth, and childhood insulin resistance. South Asians \u2013 Canada\u2019s largest minority group \u2013 and women of reproductive age are vulnerable to B12 deficiency. This study aimed to assess the prevalence of and factors associated with B12 deficiency and suboptimal B12 status in a convenience sample of young adult women of South Asian and European descent in Metro Vancouver. We measured serum B12, holotranscobalamin, plasma methylmalonic acid, red blood cell and plasma folate, and hematologic parameters in 206 nonpregnant, healthy women aged 19\u201335 years. Categorization for B12 status adhered to serum B12 cutoffs for deficiency (&lt;148 pmol\/L) and suboptimal B12 status (148\u2013220 pmol\/L). We collected demographic, lifestyle, and dietary intake data and conducted genotyping for common genetic variants linked to B-vitamin metabolism. The prevalence of deficiency and suboptimal B12 status were 14% and 20%, respectively. Serum vitamin B12 concentrations were negatively associated with oral contraceptive use and first-generation immigrant status, and positively with dietary B12 intake and B12 supplement use. The prevalence of B12 inadequacy in this sample of highly educated women is higher than in the general Canadian population. In light of maternal and fetal health risks associated with B12 inadequacy in early-pregnancy, practitioners should consider monitoring B12 status before and during early pregnancy, especially in immigrants and women with low dietary B12 intakes including non-users of vitamin supplements. <\/jats:p>","DOI":"10.1139\/apnm-2015-0200","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T21:36:23Z","timestamp":1440192983000},"page":"1279-1286","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["High prevalence of suboptimal vitamin B<sub>12<\/sub> status in young adult women of South Asian and European ethnicity"],"prefix":"10.1139","volume":"40","author":[{"given":"Teo A.W.","family":"Quay","sequence":"first","affiliation":[{"name":"Food Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa H.","family":"Schroder","sequence":"additional","affiliation":[{"name":"Food Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Jeruszka-Bielak","sequence":"additional","affiliation":[{"name":"Food Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyang","family":"Li","sequence":"additional","affiliation":[{"name":"Food Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Devlin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, University of British Columbia, British Columbia, Canada."},{"name":"Child and Family Research Institute, Vancouver British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan I.","family":"Barr","sequence":"additional","affiliation":[{"name":"Food Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Lamers","sequence":"additional","affiliation":[{"name":"Food Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada."},{"name":"Child and Family Research Institute, Vancouver British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"issue":"1","key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ajcn\/78.1.3","volume":"78","author":"Antony A.C.","year":"2003","journal-title":"Am. 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