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The aim of this study was to assess the consequences of different periods of paradoxical sleep deprivation (PSD) and recovery from PSD on lipid profile, oral glucose tolerance test (OGTT) results, and changes in insulin, corticosterone, ghrelin, and leptin concentrations. Three-month-old male Wistar rats weighing 250\u2013350 g were submitted to 24, 96, or 192 h of PSD or 192 h of PSD with 480 h of recovery. The PSD was induced by the multiple platforms method. Subsequently, the animals were submitted to an OGTT. One day later, the animals were killed and the levels of triglycerides, total cholesterol, lipoproteins (low-density lipoprotein, very-low-density lipoprotein, and high-density lipoprotein), insulin, ghrelin, leptin, and corticosterone in plasma were quantified. There was a progressive decrease in body weight with increasing duration of PSD. The PSD induced basal hypoglycemia over all time periods evaluated. Evaluation of areas under the curve revealed progressive hypoglycemia only after 96 and 192 h of PSD. There was an increase in corticosterone levels after 192 h of PSD. We conclude that PSD induces alterations in metabolism that are reversed after a recovery period of 20 days.<\/jats:p>","DOI":"10.1139\/apnm-2015-0337","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T17:34:14Z","timestamp":1446831254000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of different periods of paradoxical sleep deprivation and sleep recovery on lipid and glucose metabolism and appetite hormones in rats"],"prefix":"10.1139","volume":"41","author":[{"given":"Malinalli","family":"Brianza-Padilla","sequence":"first","affiliation":[{"name":"Posgrado en Biolog\u00eda Experimental, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, CP 09340, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herlinda","family":"Bonilla-Jaime","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n, \u00c1rea de Biolog\u00eda Conductual y Reproductiva, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Av. 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