{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:40:00Z","timestamp":1770511200188,"version":"3.49.0"},"reference-count":60,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p> The \u03b2-2 and \u03b2-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18\u201350 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (p = 0.019, 2.5 kg) and BMI (p = 0.019, 0.88 kg\/m<jats:sup>2<\/jats:sup>) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (p = 0.036), in addition to an interaction with exercise for fat mass (p = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (p = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles. <\/jats:p>","DOI":"10.1139\/apnm-2015-0425","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T22:35:50Z","timestamp":1448490950000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention"],"prefix":"10.1139","volume":"41","author":[{"given":"Barbara","family":"Szendrei","sequence":"first","affiliation":[{"name":"Laboratory of Exercise Physiology Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, Technical University of Madrid, Ciudad Universitaria de Madrid, Calle Mart\u00edn Fierro 7. 28040 Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domingo","family":"Gonz\u00e1lez-Lamu\u00f1o","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics, School of Medicine, University of Cantabria, Avenida Cardenal Herrera Oria s\/n, 39011, Santander, Spain."},{"name":"Department of Medical and Surgery Sciences, Faculty of Medicine, University of Cantabria -IDIVAL, Marqu\u00e9s de Valdecilla Research Institute, Avenida Cardenal Herrera Oria s\/n, 39011, Santander, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Amigo","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics, School of Medicine, University of Cantabria, Avenida Cardenal Herrera Oria s\/n, 39011, Santander, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan","family":"Wang","sequence":"additional","affiliation":[{"name":"FIMS Reference Collaborating Centre of Sports Medicine for Anti-Doping Research, University of Brighton, Welkin Science Laboratories, 30 Carlisle Road, Eastbourne BN20 7SN, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannis","family":"Pitsiladis","sequence":"additional","affiliation":[{"name":"FIMS Reference Collaborating Centre of Sports Medicine for Anti-Doping Research, University of Brighton, Welkin Science Laboratories, 30 Carlisle Road, Eastbourne BN20 7SN, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro J.","family":"Benito","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Physiology Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, Technical University of Madrid, Ciudad Universitaria de Madrid, Calle Mart\u00edn Fierro 7. 28040 Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Gomez-Candela","sequence":"additional","affiliation":[{"name":"Nutrition Department, Hospital La Paz Health Research Institute, University Autonoma of Madrid, Paseo de la Castellana, 261.28046, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Physiology Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, Technical University of Madrid, Ciudad Universitaria de Madrid, Calle Mart\u00edn Fierro 7. 28040 Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Cupeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Physiology Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, Technical University of Madrid, Ciudad Universitaria de Madrid, Calle Mart\u00edn Fierro 7. 28040 Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PRONAF Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11632"},{"key":"refg2\/ref2","first-page":"151","volume":"3","author":"Acharya S.D.","year":"2009","journal-title":"Patient Prefer. Adherence"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800625"},{"issue":"1","key":"refg4\/ref4","doi-asserted-by":"crossref","first-page":"228S","DOI":"10.1093\/ajcn\/55.1.228s","volume":"55","author":"Arner P.","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330612"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500000891"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-010-9361-1"},{"issue":"1","key":"refg8\/ref8","first-page":"E11","volume":"264","author":"Blaak E.E.","year":"1993","journal-title":"Am. J. Physiol."},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.528"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181844179"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2706"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-015-0154-1"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330605"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000063084"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00894.x"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803015"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1057"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181949333"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.10.1657"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.12.2149"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002695"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2007.07.017"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119014"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.43"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.88"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01871.x"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1006\/pulp.1995.1001"},{"issue":"6","key":"refg29\/ref29","first-page":"E909","volume":"275","author":"Hagstrom-Toft E.","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"1985","key":"refg30\/ref30","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1152\/jappl.2000.89.3.977","volume":"89","author":"Hunter G.R.","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.327"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801063"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.90"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.suppl_1.6"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802883"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119854"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1038\/nature14177"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2005.02.015"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802129"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1326.2002.00227.x"},{"issue":"8","key":"refg41\/ref41","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/jn\/133.8.2549","volume":"133","author":"Martinez J.A.","year":"2003","journal-title":"J. Nutr."},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00251-2"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801168"},{"issue":"5","key":"refg44\/ref44","doi-asserted-by":"crossref","first-page":"E740","DOI":"10.1152\/ajpendo.2001.280.5.E740","volume":"280","author":"Monroe M.B.","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2008.12.001"},{"issue":"2","key":"refg46\/ref46","first-page":"51S","volume":"6","author":"National Institutes of Health","year":"1998","journal-title":"National Institutes of Health. Obes. Res."},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080232"},{"key":"refg48\/ref48","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000085648.65419.17"},{"key":"refg49\/ref49","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.97"},{"key":"refg50\/ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2013.07.004"},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.32781"},{"key":"refg52\/ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-015-4012-1"},{"key":"refg53\/ref53","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.130"},{"key":"refg54\/ref54","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1950"},{"key":"refg55\/ref55","doi-asserted-by":"publisher","DOI":"10.1038\/nature14132"},{"key":"refg56\/ref56","doi-asserted-by":"publisher","DOI":"10.1038\/ng.686"},{"key":"refg57\/ref57","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.10.1709"},{"key":"refg58\/ref58","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802248"},{"key":"refg59\/ref59","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2000.7708"},{"key":"refg60\/ref60","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330604"},{"key":"refg61\/ref61","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-1100"}],"container-title":["Applied Physiology, Nutrition, and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/apnm-2015-0425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/apnm-2015-0425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:17:38Z","timestamp":1751469458000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/apnm-2015-0425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1139\/apnm-2015-0425"],"URL":"https:\/\/doi.org\/10.1139\/apnm-2015-0425","relation":{},"ISSN":["1715-5312","1715-5320"],"issn-type":[{"value":"1715-5312","type":"print"},{"value":"1715-5320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"2015-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}