{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:15:17Z","timestamp":1751516117209,"version":"3.41.0"},"reference-count":34,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p> Histamine is a potent vasodilator that has been found to increase during exercise. We tested the hypothesis that histamine would attenuate blood pressure (BP), cardiac output (CO), and vascular resistance responses to short-term, submaximal dynamic exercise during H<jats:sub>2<\/jats:sub> receptor blockade. Fourteen healthy men (20\u201329 years of age) were studied. Systolic (SBP), diastolic (DBP), and mean arterial (MAP) BP and heart rate (HR) were assessed at rest and during the last minute of 10 min of submaximal cycling exercise (60% of peak oxygen consumption) in the absence and presence of histamine H<jats:sub>2<\/jats:sub> receptor blockade (ranitidine, 300 mg). Stroke volume (SV) (impedance cardiography) and plasma norepinephrine (NE) were measured, and CO, rate \u00d7 pressure product (RPP), and total peripheral resistance (TPR) were calculated. Plasma levels of histamine were also measured. H<jats:sub>2<\/jats:sub> blockade had no effects on any variables at rest. During exercise, SBP (184 \u00b1 3 mm Hg vs. 166 \u00b1 2 mm Hg), MAP (121 \u00b1 2 mm Hg vs. 112 \u00b1 5 mm Hg), and RPP (25.9 \u00b1 0.8 \u00d7 10<jats:sup>3<\/jats:sup> mm Hg\u00b7beats\/min vs. 23.5 \u00b1 0.8 \u00d7 10<jats:sup>3<\/jats:sup> mm Hg\/beats\u00b7min) were greater during blocked conditions (P &lt; 0.05), and an interaction was observed for TPR. SV, DBP, HR, and NE levels were unaffected by blockade. Plasma histamine increased from 1.83 \u00b1 0.14 ng\/mL at rest to 2.33 \u00b1 0.23 ng\/mL during exercise (P &lt; 0.05) and was not affected by H<jats:sub>2<\/jats:sub> blockade (1.56 \u00b1 0.23 ng\/mL vs. 1.70 \u00b1 0.24 ng\/mL). These findings suggest that, during submaximal exercise, histamine attenuates BP, vascular resistance, and the work of the heart via activation of H<jats:sub>2<\/jats:sub> receptors and that these effects occurred primarily in the vasculature and not in the myocardium. <\/jats:p>","DOI":"10.1139\/apnm-2015-0450","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T22:44:00Z","timestamp":1454971440000},"page":"605-610","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Histamine H<sub>2<\/sub> receptor blockade augments blood pressure responses to acute submaximal exercise in males"],"prefix":"10.1139","volume":"41","author":[{"given":"Hyung-Woo","family":"Doh","sequence":"first","affiliation":[{"name":"Graduate School of Physical Education, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L.","family":"Stebbins","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA 95616, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Graduate School of Physical Education, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joonsung","family":"Park","sequence":"additional","affiliation":[{"name":"Graduate School of Physical Education, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosung","family":"Nho","sequence":"additional","affiliation":[{"name":"Graduate School of Physical Education, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of Physical Education, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1975.tb07571.x"},{"key":"refg2\/ref2","first-page":"1583","volume":"25","author":"Brody M.J.","year":"1966","journal-title":"Fed. 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