{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:11:17Z","timestamp":1769260277047,"version":"3.49.0"},"reference-count":37,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p> Exercise-induced dyspnea is common among adolescents and young adults and often originates from exercise-induced bronchoconstriction (EIB). Sometimes, dyspnea corresponds to exercise-induced laryngospasm (EILO), which is a paradoxical decrease in supraglottic\/glottic area. Vitamin D deficiency, which occurs frequently at northern latitudes, might favor laryngospasm by impairing calcium transport and slowing striate muscle relaxation. The aim of this study was to evaluate whether vitamin D status has an influence on bronchial and laryngeal responses to exercise in young, healthy athletes. EIB and EILO were investigated during winter in 37 healthy competitive rowers (24 males; age range 13\u201325 years), using the eucapnic voluntary hyperventilation test (EVH). EIB was diagnosed when forced expiratory volume in the first second decreased by 10%, EILO when maximum mid-inspiratory flow (MIF<jats:sub>50<\/jats:sub>) decreased by 20%. Most athletes (86.5%) had vitamin D deficiency (below 30 ng\/mL), 29 mild-moderate (78.4%) and 3 severe (8.1%). EVH showed EIB in 10 subjects (27%), EILO in 16 (43.2%), and combined EIB and EILO in 6 (16.2%). Athletes with EILO had lower vitamin D (19.1 ng\/mL vs. 27.0 ng\/mL, p &lt; 0.001) and higher parathyroid hormone (30.5 pg\/mL vs. 19.2 pg\/mL, p = 0.006) levels. The degree of laryngoconstriction (post-EVH MIF<jats:sub>50<\/jats:sub> as a percentage of pre-EVH MIF<jats:sub>50<\/jats:sub>) was related directly with vitamin D levels (r = 0.51; p = 0.001) and inversely with parathyroid hormone levels (r = \u20130.53; p = 0.001). We conclude that vitamin D deficiency is common during winter in young athletes living above the 40th parallel north and favors laryngospasm during exercise, probably by disturbing calcium homeostasis. This effect may negatively influence athletic performance. <\/jats:p>","DOI":"10.1139\/apnm-2015-0517","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T22:39:29Z","timestamp":1457044769000},"page":"735-740","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Vitamin D deficiency and exercise-induced laryngospasm in young competitive rowers"],"prefix":"10.1139","volume":"41","author":[{"given":"Enrico","family":"Heffler","sequence":"first","affiliation":[{"name":"Respiratory Medicine and Allergy, AOU \u201cPoliclinico-Vittorio Emanuele\u201d, Department of Clinical and Experimental Medicine, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Bonini","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, \u201cSapienza\u201d University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Brussino","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Torino, Via Genova 3, 10126 Torino, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Solidoro","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Citt\u00e0 della Salute e della Scienza, Via Genova 3, 10126 Torino, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Guida","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Torino, Via Genova 3, 10126 Torino, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Boita","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Torino, Via Genova 3, 10126 Torino, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Nicolosi","sequence":"additional","affiliation":[{"name":"Respiratory Medicine and Allergy, AOU \u201cPoliclinico-Vittorio Emanuele\u201d, Department of Clinical and Experimental Medicine, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Bucca","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Torino, Via Genova 3, 10126 Torino, Italy."},{"name":"Department of Pneumology, Citt\u00e0 della Salute e della Scienza, Via Genova 3, 10126 Torino, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.3"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-005-0084-y"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.35.5.344"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000149"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1407552"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02728.x"},{"key":"refg7\/ref7","first-page":"A730","volume":"1141","author":"Bucca C.","year":"1990","journal-title":"Am. 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