{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:04:47Z","timestamp":1778591087734,"version":"3.51.4"},"reference-count":41,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p> Short-term intake of a high-fat diet aggravates postprandial glucose metabolism; however, the dose\u2013response relationship has not been investigated. We hypothesized that short-term intake of a eucaloric low-carbohydrate\/high-fat diet (LCHF) would aggravate postprandial glucose metabolism and circulating adhesion molecules in healthy males. Seven healthy young males (mean \u00b1 SE; age: 26 \u00b1 1 years) consumed either a eucaloric control diet (C, approximately 25% fats), a eucaloric intermediate-carbohydrate\/intermediate-fat diet (ICIF, approximately 50% fats), or an LCHF (approximately 70% fats) for 3 days. An oral meal tolerance test (MTT) was performed after the 3-day dietary intervention. The concentrations of plasma glucose, insulin, glucagon-like peptide-1 (GLP-1), intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 (VCAM-1) were determined at rest and during MTT. The incremental area under the curve (iAUC) of plasma glucose concentration during MTT was significantly higher in LCHF than in C (P = 0.009). The first-phase insulin secretion indexes were significantly lower in LCHF than in C (P = 0.04). Moreover, the iAUC of GLP-1 and VCAM-1 concentrations was significantly higher in LCHF than in C (P = 0.014 and P = 0.04, respectively). The metabolites from ICIF and C were not significantly different. In conclusion, short-term intake of eucaloric diet containing a high percentage of fats in healthy males excessively increased postprandial glucose and VCAM-1 concentrations and attenuated first-phase insulin release. <\/jats:p>","DOI":"10.1139\/apnm-2015-0702","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T14:15:31Z","timestamp":1469456131000},"page":"895-902","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Short-term high-fat diet alters postprandial glucose metabolism and circulating vascular cell adhesion molecule-1 in healthy males"],"prefix":"10.1139","volume":"41","author":[{"given":"Shigeharu","family":"Numao","sequence":"first","affiliation":[{"name":"Department of Health and Sports Sciences, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan."},{"name":"Waseda Institute for Sport Sciences, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawano","sequence":"additional","affiliation":[{"name":"Faculty of Letters, Kokushikan University, 4-28-1 Setagaya, Setagaya-ku, Tokyo 154-8515, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Endo","sequence":"additional","affiliation":[{"name":"Japan Institute of Sports Sciences 3-15-1 Nishigaoka, Kita-ku, Tokyo 115-0056."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Yamada","sequence":"additional","affiliation":[{"name":"Waseda Institute for Sport Sciences, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Faculty of Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku, Tokyo 162-8480, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Konishi","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuo","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/ajcn\/79.4.682","volume":"79","author":"Aljada A.","year":"2004","journal-title":"Am. 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