{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:15:28Z","timestamp":1793348128950,"version":"4.5.0"},"reference-count":52,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p> Kolaviron (KV), an active complex of at least 3 compounds in Garcinia kola seed, which is known for its antioxidant and anti-inflammatory activity, was investigated for its gastro-protective effect in the stomach of rats subjected to ischemia\/reperfusion-induced gastric ulceration. Male adult Wistar rats (180\u2013210 g) were randomized into 6 groups (n = 15) as follows: (i) control, (ii) ulcerated untreated (UU), (iii) KV alone (KVA), (iv) KV + ulcer (KVU), (v) ulcer + KV (UKV), and (vi) ulcer + omeprazole (20 mg\/kg). Ulcer was induced through ischemia\/reperfusion method after 2 weeks of daily oral KV (100 mg\/kg). Rats were weighed daily, and gastric acid secretion, ulcer scores, hematological, biochemical, and histological variables were assessed 1 h after induction at 3 and 7 days post-ulceration. Body weight decreased in KVA (179.1 \u00b1 1.6 g), and KVU (170.1 \u00b1 2.2 g) compared with UU (199.0 \u00b1 1.4 g). Gastric acid secretion decreased significantly in KVU after 1 h and 3 days post-ulceration (0.27 \u00b1 0.03 mEq\/L; 0.49 \u00b1 0.02 mEq\/L) compared with UU (0.60 \u00b1 0.06 mEq\/L; 0.85 \u00b1 0.29 mEq\/L), respectively. There was significant reduction in neutrophil\/lymphocyte ratio of KVA (0.29 \u00b1 0.06) and KVU (0.35 \u00b1 0.02) compared with UU (0.54 \u00b1 0.04). Malondialdehyde level decreased significantly with concomitant increase in anti-oxidative activities and nitric oxide level in the KV treated groups (KVA, KVU, UKV) compared with UU. In conclusion, treatment with KV protects the stomach by reducing gastric acid secretion, promoting antioxidant activity and suppressing action of reactive oxygen species. <\/jats:p>","DOI":"10.1139\/apnm-2017-0138","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T21:33:56Z","timestamp":1503696836000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Kolaviron attenuates ischemia\/reperfusion injury in the stomach of rats"],"prefix":"10.1139","volume":"43","author":[{"given":"Olugbenga Adeola","family":"Odukanmi","sequence":"first","affiliation":[{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."},{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeola Temitope","family":"Salami","sequence":"additional","affiliation":[{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."},{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onaara Peter","family":"Ashaolu","sequence":"additional","affiliation":[{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."},{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeoti Gbemisola","family":"Adegoke","sequence":"additional","affiliation":[{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."},{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Babafemi","family":"Olaleye","sequence":"additional","affiliation":[{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."},{"name":"Laboratory for Gastrointestinal Secretions and Inflammation Research, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","first-page":"339","volume":"78","author":"Vizi E.S.","year":"1982","journal-title":"Eur. 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