{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:52:02Z","timestamp":1783511522037,"version":"3.55.0"},"reference-count":56,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p> Atherosclerosis is a chronic disease that can seriously endanger human life. Folic acid supplementation modulates several disorders, including atherosclerosis, via its antiapoptotic and antioxidative properties. This study investigated whether folic acid alleviates atherogenesis by restoring homocysteine levels and antioxidative capacity in atherosclerosis Wistar rats. To this end, 28 Wistar rats were randomly divided into 4 groups (7 rats\/group) as follows: (i) wild-type group, fed only the AIN-93 semi-purified rodent diet (folic acid: 2.1 mg\/kg); (ii) high-fat + folic acid-deficient group (HF+DEF) (folic acid: 0.2 mg\/kg); (iii) high-fat + normal folic acid group (folic acid: 2.1 mg\/kg); and (iv) high-fat + folic acid-supplemented group (folic acid: 4.2 mg\/kg). After 12 weeks, histopathological changes in the atherosclerotic lesions of the aortic arch were determined. In addition, serum folate levels, plasma homocysteine levels, plasma S-adenosyl-homocysteine levels, antioxidant status, oxidant status, and lipid profiles were evaluated. The results show aggravated atherosclerotic lesions in the HF+DEF group. Folic acid supplementation increased concentrations of serum folate. Further, folic acid supplementation increased high-density lipoprotein-cholesterol, decreased plasma homocysteine levels, and improved antioxidant capacity in atherogenic rats. These findings are consistent with the hypothesis that folic acid alleviates atherogenesis by reducing plasma homocysteine levels and improving antioxidant capacity in rats fed a high-fat diet. <\/jats:p>","DOI":"10.1139\/apnm-2017-0158","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T21:34:27Z","timestamp":1496439267000},"page":"1015-1022","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats"],"prefix":"10.1139","volume":"42","author":[{"given":"Shanshan","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Hospital of Tianjin Medical University, Tianjin 300052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","first-page":"M8","volume":"19","author":"Assmann G.","year":"1998","journal-title":"Eur. Heart. J."},{"key":"refg2\/ref2","first-page":"559","volume":"54","author":"Bennani-Kabchi N.","year":"1999","journal-title":"Therapie"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1869-2"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055227"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1161\/hq0302.105369"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2014.06.004"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.10.014"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.12.020"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510005052"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13009"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-1891(02)00254-9"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0801(199609)10:5<205::AID-BMC589>3.0.CO;2-P"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-10-20"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.4314\/ajpsy.v15i1.3"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1038\/srep08506"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2007.07.010"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-015-1956-7"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-1102"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00543-3"},{"key":"refg20\/ref20","doi-asserted-by":"crossref","first-page":"3731S","DOI":"10.1093\/jn\/133.11.3731S","volume":"133","author":"Kim Y.I.","year":"2003","journal-title":"J. Nutr."},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1007-3"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00538"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104713"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.03.045"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9556-9"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.03.032"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1076"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.107441"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","unstructured":"Marti-Carvajal, A.J., Sola, I., and Lathyris, D. 2015. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst. Rev. 1: CD006612. 10.1002\/14651858.CD006612.pub4. 25590290.","DOI":"10.1002\/14651858.CD006612.pub4"},{"key":"refg31\/ref31","first-page":"111","volume":"56","author":"McCully K.S.","year":"1969","journal-title":"Am. J. Pathol."},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2015.1010516"},{"key":"refg33\/ref33","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1161\/01.ATV.20.3.836","volume":"20","author":"McGill H.C.","year":"2000","journal-title":"PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler. Thromb. Vasc. Biol."},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100694"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.11.007"},{"key":"refg36\/ref36","first-page":"376","volume":"16","author":"Ponziani F.R.","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"refg37\/ref37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.33549\/physiolres.930520","volume":"54","author":"Racek J.","year":"2005","journal-title":"Physiol. Res."},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2003.11.004"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2008.00585.x"},{"key":"refg40\/ref40","doi-asserted-by":"crossref","first-page":"1731S","DOI":"10.1093\/jn\/136.6.1731S","volume":"136","author":"Refsum H.","year":"2006","journal-title":"J. Nutr."},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.5.359"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.679084"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1556\/650.2015.30201"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3721"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2014.06.013"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.5.565"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.2174\/138161209789058093"},{"key":"refg48\/ref48","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60692-4"},{"key":"refg49\/ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-014-0729-5"},{"key":"refg50\/ref50","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11596"},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.3390\/nu7010074"},{"key":"refg52\/ref52","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12510"},{"key":"refg53\/ref53","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr20510.1093\/eurheartj\/ehr217"},{"key":"refg54\/ref54","doi-asserted-by":"publisher","DOI":"10.1042\/bst0290358"},{"key":"refg55\/ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.04.019"},{"key":"refg56\/ref56","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2954"}],"container-title":["Applied Physiology, Nutrition, and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/apnm-2017-0158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/apnm-2017-0158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:32:00Z","timestamp":1751470320000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/apnm-2017-0158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1139\/apnm-2017-0158"],"URL":"https:\/\/doi.org\/10.1139\/apnm-2017-0158","relation":{},"ISSN":["1715-5312","1715-5320"],"issn-type":[{"value":"1715-5312","type":"print"},{"value":"1715-5320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"2017-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}