{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:02:04Z","timestamp":1789801324993,"version":"4.0.1"},"reference-count":70,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p> Perfusion of hearts with extracts of Ilex paraguariensis (IP\/mate) appears to reduce ischemia\/reperfusion (I\/R) injury. To determine if oral consumption of IP\/mate can provide similar cardioprotection, short-term consumption was investigated alone or in association with exercise in rats. Animals were grouped into control (C), IP\/mate consumption (M), exercise (E), and exercise with mate (E+M). M and E+M groups consumed IP\/mate (1 g\u00b7kg<jats:sup>\u22121<\/jats:sup> body weight in 1 mL water) by gavage. E and E+M groups swam 7\u00d7 per week for 30 min carrying an additional 5% of body weight. After 1 week, hearts were tested ex vivo to measure left ventricle developed pressure (LVDP), systolic and end diastolic pressure (LVSP\/LVEDP), maximum velocity of contraction and relaxation (dP\/dt+ and dP\/dt\u2013) during I\/R and infarction size. In addition, cardiac tissue was analyzed for oxidative stress by lipid peroxidation and protein carbonyl levels along with activity of catalase and superoxide dismutase (SOD). LVDP was higher in hearts from M and E groups as well as decreased infarction sizes than others. At the end of reperfusion, dP\/dt+ was increased in E and M and dP\/dt\u2013 was higher in M. LVSP was higher in M and E compared with C. Protein carbonyl and thiobarbituric acid reactive substances levels were higher in M while SOD activity was increased in E. No differences were observed in other activities. The results suggest that short-term consumption of IP\/mate has protective effects on heart I\/R injury similar to exercise, but the combination of these interventions appears to contradict the beneficial adaptations from exercise. <\/jats:p>","DOI":"10.1139\/apnm-2017-0213","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T21:35:21Z","timestamp":1499376921000},"page":"1149-1157","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Short-term consumption of <i>Ilex paraguariensis<\/i> extracts protects isolated hearts from ischemia\/reperfusion injury and contradicts exercise-mediated cardioprotection"],"prefix":"10.1139","volume":"42","author":[{"given":"F\u00e1bio","family":"Cahu\u00ea","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica do Exerc\u00edcio e Motores Moleculares, Escola de Educa\u00e7\u00e3o F\u00edsica e Desportos, Universidade Federal 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