{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:00:56Z","timestamp":1788836456696,"version":"build-2803163510"},"reference-count":34,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p> Sprint interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin\/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT, body mass and fat percentage were measured and oral glucose tolerance tests performed in 20 young healthy participants (7 females). Blood gene expression profiles (all 7 mammalian sirtuin genes and 15 enzymes involved in conversion of tryptophan, bioavailable vitamin B3, and metabolic precursors to NAD). NAD\/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD\/NADP, and regulation of components of the sirtuin\/NAD system (NAMPT, NMNAT1, CD38, and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin\/NAD system to SIT. <\/jats:p>","DOI":"10.1139\/apnm-2017-0224","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T21:36:04Z","timestamp":1505338564000},"page":"84-93","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system"],"prefix":"10.1139","volume":"43","author":[{"given":"Stuart R.","family":"Gray","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom P.","family":"Aird","sequence":"additional","affiliation":[{"name":"The Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Farquharson","sequence":"additional","affiliation":[{"name":"The Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham W.","family":"Horgan","sequence":"additional","affiliation":[{"name":"Biomathematics and Statistics Scotland, Foresterhill, Aberdeen, AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Fisher","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wilson","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth E.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Anderson","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart R.","family":"Davis","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice E.","family":"Drew","sequence":"additional","affiliation":[{"name":"The Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","first-page":"p. 26","volume":"2016","author":"Andraos S.","year":"2016","journal-title":"Book of abstracts NuGO Week"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-9-3"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2015-000056"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.10.2911"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01095.2004"},{"key":"refg6\/ref6","unstructured":"Capewell, S., Allender, S., Critchley, J., Lloyd-Williams, F., O\u2019Flaherty, M., Rayner, M., and Scarborough, P. 2009. 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