{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:08:12Z","timestamp":1790554092707,"version":"4.1.0"},"reference-count":68,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p> Allium hirtifolium Boiss and Astragalus hamosus L. are mentioned in Iranian traditional medicine documentation as therapy for a kind of dementia with the features and symptoms similar to those of Alzheimer\u2019s disease (AD). In the present study, the effects of these herbs on neuro-inflammation and memory have been evaluated as new therapies in amyloid beta (A\u03b2)-induced memory impairment model. Separate groups of rats were fed with A. hirtifolium or A. hamosus extract (both 100 mg\/(kg\u00b7day)<jats:sup>\u22121<\/jats:sup>) started 1 week before stereotaxic surgery to 24 h before behavioral testing (totally, for 16 successive days). The effects of oral administration of mentioned extracts on the memory and neuro-inflammation were assessed in the A\u03b2-injected rats. The results of this study showed that oral administration of both A. hirtifolium and A. hamosus improved the memory, examined by using Y-maze test and shuttle box apparatus. Also, Western blotting analysis of cyclooxygenase-2, interleukin-1\u03b2, and tumor necrosis factor-\u03b1 showed that these herbs have ameliorating effects against the neuro-inflammation caused by A\u03b2. These findings suggest that the use of A. hirtifolium and A. hamosus as herbal therapy may be suitable for decreasing AD-related symptoms and treatment of other neurodegenerative disorders. <\/jats:p>","DOI":"10.1139\/apnm-2017-0585","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T22:41:04Z","timestamp":1513809664000},"page":"558-564","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Dietary supplementation with <i>Allium hirtifolium<\/i> and\/or <i>Astragalus hamosus<\/i> improved memory and reduced neuro-inflammation in the rat model of Alzheimer\u2019s disease"],"prefix":"10.1139","volume":"43","author":[{"given":"Zahra","family":"Bahaeddin","sequence":"first","affiliation":[{"name":"Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asal","family":"Yans","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Khodagholi","sequence":"additional","affiliation":[{"name":"NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamim","family":"Sahranavard","sequence":"additional","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2015.10.001"},{"key":"refg2\/ref2","first-page":"1414","volume":"42","author":"Ahmadian-Attari M.M.","year":"2013","journal-title":"Iran. 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