{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:19:08Z","timestamp":1790713148918,"version":"4.1.0"},"reference-count":55,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Fibroblast growth factor 21 (FGF21), follistatin and leukocyte cell-derived chemotaxin 2 (LECT2) are novel hepatokines that are modulated by metabolic stresses. This study investigated whether exercise intensity modulates the hepatokine response to acute exercise. Ten young, healthy men undertook three 8-h experimental trials: moderate-intensity exercise (MOD; 55% peak oxygen uptake), high-intensity exercise (HIGH; 75% peak oxygen uptake), and control (CON; rest), in a randomised, counterbalanced order. Exercise trials commenced with a treadmill run of varied duration to match gross exercise energy expenditure between trials (MOD vs HIGH; 2475 \u00b1 70 vs 2488 \u00b1 58 kJ). Circulating FGF21, follistatin, LECT2, glucagon, insulin, glucose and nonesterified fatty acids (NEFA) were measured before exercise and at 0, 1, 2, 4, and 7 h postexercise. Plasma FGF21 concentrations were increased up to 4 h postexercise compared with CON (P \u2264 0.022) with greater increases observed at 1, 2, and 4 h postexercise during HIGH versus MOD (P \u2264 0.025). Irrespective of intensity (P \u2265 0.606), plasma follistatin concentrations were elevated at 4 and 7 h postexercise (P \u2264 0.053). Plasma LECT2 concentrations were increased immediately postexercise (P \u2264 0.046) but were not significant after correcting for plasma volume shifts. Plasma glucagon (1 h; P = 0.032) and NEFA (4 and 7 h; P \u2264 0.029) responses to exercise were accentuated in HIGH versus MOD. These findings demonstrate that acute exercise augments circulating FGF21 and follistatin. Exercise-induced changes in FGF21 are intensity-dependent and may support the greater metabolic benefit of high-intensity exercise.<\/jats:p>","DOI":"10.1139\/apnm-2018-0818","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T11:52:28Z","timestamp":1566906748000},"page":"1065-1072","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["Effect of exercise intensity on circulating hepatokine concentrations in healthy men"],"prefix":"10.1139","volume":"44","author":[{"given":"Scott A.","family":"Willis","sequence":"first","affiliation":[{"name":"National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK."},{"name":"NIHR Leicester Biomedical Research Centre, Leicester LE3 9QD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Sargeant","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK."},{"name":"NIHR Leicester Biomedical Research Centre, Leicester LE3 9QD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice E.","family":"Thackray","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK."},{"name":"NIHR Leicester Biomedical Research Centre, Leicester LE3 9QD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Yates","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre, Leicester LE3 9QD, UK."},{"name":"Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Stensel","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK."},{"name":"NIHR Leicester Biomedical Research Centre, Leicester LE3 9QD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guruprasad P.","family":"Aithal","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK."},{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2QL, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"King","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK."},{"name":"NIHR Leicester Biomedical Research Centre, Leicester LE3 9QD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.762922"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.01.046"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2803-y"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064800"},{"issue":"2","key":"refg5\/ref5","first-page":"90","volume":"5","author":"Borg G.A.","year":"1973","journal-title":"Med. 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