{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:05:50Z","timestamp":1777518350136,"version":"3.51.4"},"reference-count":33,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> The present study designed and evaluated a polyherbal premix comprising Macrotyloma uniflorum, whey protein, Zingiber officinale, and Mentha piperita. Animals were fed a high-fat diet (HFD) for 30 days and were daily administered the premix (1.5 g\/kg) in milk (PM) and water (PW), aerobic exercise (AE), premix in milk and water along with AE (PMAE and PWAE), ferulic acid (100 mg\/kg), and the reference drug fluoxetine (6 mg\/kg). All treatments showed significant reduction in food intake, weight gain, abdominal circumference, and body mass index compared with their initial values. All treatments generated a faster peak of the satiety marker cholecystokinin compared with the HFD group and control groups; PMAE and PWAE exhibited sustained satiety. The HFD-elevated blood glucose levels were significantly attenuated on the 30th day by all treatments when compared with their 15th day and basal values; PMAE exhibited the best results. All treatments significantly attenuated the HFD-elevated serum insulin, homeostasis model assessment of insulin resistance, C-reactive protein, triglycerides, total cholesterol, very-low-density lipoprotein, and low-density lipoprotein levels and significantly restored the HFD-depleted high-density lipoprotein and adiponectin levels. HFD-elevated thiobarbituric acid reactive substances values were attenuated successfully and the HFD-depleted reduced glutathione, superoxide dismutase, and catalase levels were significantly restored by all treatments. The histological findings corroborated the biochemical results. <\/jats:p><jats:p> Novelty The polyherbal premix brought about appetite regulation and induction of satiety to control obesity in HFD-fed rats through homeostasis of energy metabolism. The premix along with exercise is a complete way to combat obesity. <\/jats:p>","DOI":"10.1139\/apnm-2019-0139","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T21:45:54Z","timestamp":1557870354000},"page":"24-34","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["A herbal premix containing <i>Macrotyloma uniflorum<\/i>, ginger, and whey curtails obesity in rats fed a high-fat diet by a novel mechanism"],"prefix":"10.1139","volume":"45","author":[{"given":"Vandana S.","family":"Panda","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Toxicology, Prin. K. M. Kundnani College of Pharmacy, Mumbai 400005, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taasin","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Prin. K. M. 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