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For decades, the capillary supply has been explored mainly in terms of evaluating the capillary numbers and their function in the supply of oxygen and substrates and the removal of metabolic byproducts. This review will focus on recent discoveries concerning the role played by capillaries in facilitating other aspects of cell regulation and maintenance, in health and disease, as well as alterations during the aging process. <\/jats:p><jats:p> Novelty Capillaries play a central role in the coordination of the vascular response that controls blood flow during contraction and the cellular responses to which they feed into. Nitric oxide is an important regulatory compound within the cardiovascular system, and a significant contributor to skeletal muscle capillary angiogenesis and vasodilatory response to agonists. The microvascular network between muscle fibres may play a critical role in the distribution of signalling factors necessary for optimal muscle satellite cell function. <\/jats:p>","DOI":"10.1139\/apnm-2019-0416","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T21:48:30Z","timestamp":1573595310000},"page":"453-462","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Capillary facilitation of skeletal muscle function in health and disease"],"prefix":"10.1139","volume":"45","author":[{"given":"Gianni","family":"Parise","sequence":"first","affiliation":[{"name":"McMaster University, Departments of Kinesiology and Medical Physics & Applied Radiation Science, Hamilton, ON L8S 4K1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral L.","family":"Murrant","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cocks","sequence":"additional","affiliation":[{"name":"Liverpool John Moores University, Research Institute for Sport and Exercise Sciences, Liverpool, L3 5UG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Snijders","sequence":"additional","affiliation":[{"name":"Maastricht University, NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Human Biology, Maastricht 6200 MD, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Baum","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Charit\u00e9-Universit\u00e4ts medizin Berlin, Berlin D-10117, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Plyley","sequence":"additional","affiliation":[{"name":"Brock University, Department of Kinesiology, St. Catharines, ON L2S 3A1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3570593"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.03.005"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1935.sp003326"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02244.x"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2011-1467"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2011-1467"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00048.2016"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1080\/10739680591003413"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00594.2015"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00480.2015"},{"key":"refg113\/ref113","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00028"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.068262"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1959.196.2.381"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.268.3.H1215"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.6.H2693"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12709"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1983.244.4.H546"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.06.003"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.08.007"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300203"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.6.C1262"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10038"},{"issue":"2","key":"refg22\/ref22","first-page":"431","volume":"189","author":"Cheung L.K.","year":"1996","journal-title":"J. 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