{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:14:11Z","timestamp":1751516051904,"version":"3.41.0"},"reference-count":46,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p> The aim of the present study was to test the hypothesis that inflammation mediates the associations among food intake, clinical-nutritional status, and plasma homocysteine (Hcys) in hemodialysis (HD) subjects. This was a cross-sectional analysis of data on 129 subjects undergoing HD (58.9% male, 61.8 \u00b1 15.5 years of age) from the cohort Nutrition and Genetics on HD outcomes (NUGE-HD study). Sociodemographic, anthropometric, and metabolic data were collected, and food intake was assessed using a quantitative food frequency questionnaire. Plasma C-reactive protein (CRP) was used as an inflammatory marker. Data were analyzed by structural equation modeling. Regarding the direct effects, complex B vitamin intake was negatively associated with body mass index, and diabetes mellitus was positively associated with CRP. Plasma CRP also showed a negative association with Hcys, and the ratio of saturated and polyunsaturated fatty acids intake showed a positive association with Hcys. Regarding indirect effects, the results showed that the relationship between the presence of diabetes mellitus and Hcys is mediated by plasma CRP. In conclusion, the ratio of saturated and polyunsaturated fatty acids had a direct effect on plasma Hcys, whereas inflammation had a direct and mediating effect on the relationship between Hcys and diabetes mellitus in HD subjects. <\/jats:p><jats:p> Novelty In end-stage renal disease, CRP influences plasma Hcys directly and also indirectly through its mediating effect. The quantity and quality of dietary fatty acids influence plasma Hcys concentrations in HD subjects. <\/jats:p>","DOI":"10.1139\/apnm-2019-0800","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T01:34:09Z","timestamp":1595036049000},"page":"845-850","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary intake, clinical-nutritional status, and homocysteine in hemodialysis subjects: the mediating role of inflammation (NUGE-HD study)"],"prefix":"10.1139","volume":"45","author":[{"given":"Karla Pereira","family":"Balbino","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, MG 36570-900, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leidjaira Lopes","family":"Juvanhol","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, MG 36570-900, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Lage","family":"Wendling","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, MG 36570-900, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Domingos","family":"Marota","sequence":"additional","affiliation":[{"name":"Division of Nephrology, S\u00e3o Jo\u00e3o Batista Hospital, Vi\u00e7osa, MG 36570-005, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline Beatriz Silva","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Nephrology, S\u00e3o Jo\u00e3o Batista Hospital, Vi\u00e7osa, MG 36570-005, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Bressan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, MG 36570-900, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Hermana Miranda","family":"Hermsdorff","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, MG 36570-900, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2007.11.007"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2010001200004"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00531-7"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12468"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9793-z"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00710111"},{"key":"refg7\/ref7","unstructured":"Brazilian Institute of Geography and Statistics. 2011. 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