{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T23:20:14Z","timestamp":1776554414803,"version":"3.51.2"},"reference-count":59,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:p> Patients with cystic fibrosis\u00a0(CF) are at high risk of fat-soluble vitamin deficiencies, even with supplementation. The contribution of a suboptimal vitamin K status to respiratory and endocrine pathophysiology in CF has been inadequately characterized. This is a cross-sectional study in adult CF patients\u00a0(\u226518 years old) from the Montreal Cystic Fibrosis Cohort. Vitamin K<jats:sub>1<\/jats:sub>\u00a0(VK1) was measured with high-performance liquid chromatography, using fasted serum samples collected during an oral glucose tolerance test\u00a0(OGTT: 2\u00a0h with plasma glucose and insulin every 30\u00a0min)\u00a0( n\u00a0=\u00a0168). Patients were categorized according to VK1 status\u00a0(suboptimal defined as\u00a0&lt;0.30\u00a0nmol\/L). Suboptimal VK1 levels were observed in 66% of patients. Patients with a suboptimal VK1 status have a higher risk of colonization with Pseudomonas aeruginosa\u00a0( p\u00a0=\u00a00.001), have lower body mass index\u00a0(BMI)\u00a0( p\u00a0=\u00a00.003), and were more likely to have exocrine pancreatic insufficiency\u00a0( p\u00a0=\u00a00.002). Using an established threshold for VK1, we did show significantly reduced OGTT-derived measures of insulin secretion in patients with a VK1 status below 0.30\u00a0nmol\/L\u00a0(first- and second-phase area under the curve (AUC)<jats:sub>INS\/GLU\u00a0<\/jats:sub>( p\u00a0=\u00a00.002 and p\u00a0=\u00a00.006), AUC<jats:sub>INS\u00a0<\/jats:sub>( p\u00a0=\u00a00.012) and AUC<jats:sub>INS\/GLU<\/jats:sub>\u00a0( p\u00a0=\u00a00.004)). Subclinical vitamin K deficiency is more common than other fat-soluble vitamin deficiencies in patients with CF. We demonstrate an association between a suboptimal VK1 status and measures of insulin secretion. We highlight the potential associations of mild vitamin K deficiency with pseudomonal colonization and lower BMI, although these need to be validated in prospective studies. <\/jats:p>","DOI":"10.1139\/apnm-2022-0163","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T21:33:40Z","timestamp":1674336820000},"page":"321-330","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Low vitamin K status in adults with cystic fibrosis is associated with reduced body mass index, insulin secretion, and increased pseudomonal colonization"],"prefix":"10.1139","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-6370","authenticated-orcid":false,"given":"Cindy","family":"Bergeron","sequence":"first","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM)","place":["Montr\u00e9al, Canada"]},{"name":"Department of Nutrition, Faculty of Medicine, Universit\u00e9 de 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