{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:09:33Z","timestamp":1751515773360,"version":"3.41.0"},"reference-count":18,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN2018-06255"],"award-info":[{"award-number":["RGPIN2018-06255"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p> The aim of this study was to determine the effect of posture changes on vascular compliance in intracranial (brain) versus extracranial vascular beds (forearm). Eighteen young adults (nine females) performed a supine-to-seated-to-standing protocol involving 5 min of rest in each position. Continuous blood pressure, middle cerebral artery (MCA) blood velocity, and brachial artery blood velocity were recorded at each posture. Three to five consecutive steady-state cardiac cycles at each posture were analyzed by a four-element lumped parameter modified Windkessel model to calculate vascular compliance. Mean arterial pressure (MAP) increased from supine to seated (76(9) vs. 81(12) mmHg; P\u00a0=\u00a00.006) and from supine to standing (76(9) vs. 82(13) mmHg; P\u00a0=\u00a00.034). Mean blood flow was greater in the MCA relative to the forearm (forearm: 40(5) mL\u00b7min<jats:sup>\u22121<\/jats:sup>, MCA: 224(17) mL\u00b7min<jats:sup>\u22121<\/jats:sup>; main effect P\u00a0&lt;\u00a00.001). Conversely, vascular resistance (forearm: 3.25(0.50) mmHg<jats:sup>\u22121<\/jats:sup>\u00b7mL\u00b7min<jats:sup>\u22121<\/jats:sup>, brain: 0.36(0.04) mmHg<jats:sup>\u22121<\/jats:sup>\u00b7mL\u00b7min<jats:sup>\u22121<\/jats:sup>; main effect P\u00a0&lt;\u00a00.001) and compliance (forearm: 0.010(0.001) mL\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>, brain: 0.005(0.001) mL\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>; main effect P\u00a0=\u00a00.001) were greater in the forearm compared to the brain. Significant main effects of posture were observed with decreasing values in upright positions for mean blood flow ( P\u00a0=\u00a00.001) in both vascular beds, but not for resistance ( P\u00a0=\u00a00.163) or compliance ( P\u00a0=\u00a00.385). There were no significant interaction effects between vascular bed and posture for mean flow ( P\u00a0=\u00a00.057), resistance ( P\u00a0=\u00a00.258), or compliance ( P\u00a0=\u00a00.329). This study provides evidence that under steady-state conditions, posture does not affect cerebrovascular compliance. <\/jats:p>","DOI":"10.1139\/apnm-2023-0447","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T21:37:13Z","timestamp":1716413833000},"page":"1210-1216","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["No influence of steady-state postural changes on cerebrovascular compliance in humans"],"prefix":"10.1139","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6505-8398","authenticated-orcid":false,"given":"Alicia M.","family":"Kells","sequence":"first","affiliation":[{"name":"School of Kinesiology, Western University","place":["London, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Erin","family":"Moir","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Western University","place":["London, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff B.","family":"Coombs","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Western University","place":["London, Canada"]},{"name":"Department of Kinesiology, McMaster University","place":["Hamilton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"D'Souza","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Western University","place":["London, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Klassen","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Western University","place":["London, Canada"]},{"name":"Department of Kinesiology, Brock University","place":["St. Catharines, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1075-4183","authenticated-orcid":false,"given":"Baraa K.","family":"Al-Khazraji","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Western University","place":["London, Canada"]},{"name":"Department of Kinesiology, McMaster University","place":["Hamilton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Kevin","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Western University","place":["London, Canada"]},{"name":"Department of Physiology and Pharmacology, Western University","place":["London, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000087"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.9.1.89"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c180021"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01634"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73658-0"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1113\/JP273557"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-8703(99)70313-3"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1976.44.6.0687"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199905000-00010"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00272.2020"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1113\/EP089533"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14039"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.8.1564"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.7.1672"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.268953"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.037937"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00940"}],"container-title":["Applied Physiology, Nutrition, and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/apnm-2023-0447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/apnm-2023-0447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:10:24Z","timestamp":1751469024000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/apnm-2023-0447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1139\/apnm-2023-0447"],"URL":"https:\/\/doi.org\/10.1139\/apnm-2023-0447","relation":{},"ISSN":["1715-5312","1715-5320"],"issn-type":[{"type":"print","value":"1715-5312"},{"type":"electronic","value":"1715-5320"}],"subject":[],"published":{"date-parts":[[2024,9,1]]},"assertion":[{"value":"2024-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}