{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:36:27Z","timestamp":1784158587251,"version":"3.55.0"},"reference-count":48,"publisher":"Canadian Science Publishing","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.en_GB"}],"funder":[{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"crossref","award":["R01OH011528"],"award-info":[{"award-number":["R01OH011528"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p> Occupational heat stress increases acute kidney injury risk. Drinking a soft drink sweetened with high fructose corn syrup further elevates this acute kidney injury risk. However, the impact of sucrose, another fructose-containing sweetener, on acute kidney injury risk remains unexplored. We tested the hypothesis that drinking a sucrose-containing sports drink increases acute kidney injury risk when compared to drinking a sugar-free sports drink during 4 h of simulated occupational heat stress. Ten healthy adults consumed a sucrose-containing or sugar-free sport drink ad libitum during 4 h exposures to wet bulb globe temperatures of \u223c28 \u00b0C. Thirty\u00a0min of work and 30\u00a0min of rest were completed each hour. Work involved treadmill walking at a fixed rate of metabolic heat production (sucrose-containing: 6.0\u00a0\u00b1\u00a01.2\u00a0W\/kg, sugar-free: 5.5\u00a0\u00b1\u00a00.9\u00a0W\/kg, p\u00a0=\u00a00.267). The product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2, normalized to urine specific gravity ([IGFBP7\u00b7TIMP-2]<jats:sub>USG<\/jats:sub>), provided an acute kidney injury risk index. Mean core (intestinal: n\u00a0=\u00a013, rectal: n\u00a0=\u00a07) temperature (sucrose-containing: 37.5\u00a0\u00b1\u00a00.1 \u00b0C, sugar-free: 37.5\u00a0\u00b1\u00a00.3 \u00b0C; p\u00a0=\u00a00.914), peak core temperature (sucrose-containing: 37.8\u00a0\u00b1\u00a00.2 \u00b0C, sugar-free: 37.9\u00a0\u00b1\u00a00.3 \u00b0C; p\u00a0=\u00a00.398), and percent changes in body mass (sucrose-containing: \u22120.5\u00a0\u00b1\u00a00.4%, sugar-free: \u22120.3\u00a0\u00b1\u00a00.6%; p\u00a0=\u00a00.386) did not differ between groups. [IGFBP7\u2219TIMP-2]<jats:sub>USG<\/jats:sub> increased in both groups (time effect: p\u00a0=\u00a00.025) with no drink ( p\u00a0=\u00a00.675) or interaction ( p\u00a0=\u00a00.715) effects. Peak change [IGFBP7\u2219TIMP-2]<jats:sub>USG<\/jats:sub> did not differ between sucrose-containing (median 0.0116 [\u22120.0012, 0.1760] (ng\/mL)<jats:sup>2<\/jats:sup>\/1000) and sugar-free (median 0.0021 [0.0003, 0.2077] (ng\/mL)<jats:sup>2<\/jats:sup>\/1000; p\u00a0=\u00a00.796). Sucrose-containing sports drink consumption during simulated occupational heat stress does not modify acute kidney injury risk when compared to sugar free-sport drink consumption. <\/jats:p>","DOI":"10.1139\/apnm-2024-0261","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T17:41:00Z","timestamp":1729014060000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of consuming a sucrose-containing sports drink on acute kidney injury risk during a 4 h simulated occupational heat stress"],"prefix":"10.1139","volume":"50","author":[{"given":"Maxime Jeanovitch","family":"Lignier","sequence":"first","affiliation":[{"name":"Indiana University School of Public Health \u2013 Bloomington","place":["Bloomington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-7208","authenticated-orcid":false,"given":"Hayden W.","family":"Hess","sequence":"additional","affiliation":[{"name":"Indiana University School of Public Health \u2013 Bloomington","place":["Bloomington, USA"]},{"name":"Center for Research and Education in Special Environments, Department of Exercise and Nutrition Sciences, University at Buffalo","place":["Buffalo, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Freemas","sequence":"additional","affiliation":[{"name":"Indiana University School of Public Health \u2013 Bloomington","place":["Bloomington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Indiana University School of Public Health \u2013 Bloomington","place":["Bloomington, USA"]},{"name":"Nutrition and Exercise Research Center, Indiana University School of Public Health \u2013 Bloomington","place":["Bloomington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-4001","authenticated-orcid":false,"given":"David","family":"Hostler","sequence":"additional","affiliation":[{"name":"Center for Research and Education in Special Environments, Department of Exercise and Nutrition Sciences, University at Buffalo","place":["Buffalo, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-3958","authenticated-orcid":false,"given":"Zachary J.","family":"Schlader","sequence":"additional","affiliation":[{"name":"Indiana University School of Public Health \u2013 Bloomington","place":["Bloomington, USA"]},{"name":"Nutrition and Exercise Research Center, Indiana University School of Public Health \u2013 Bloomington","place":["Bloomington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31821ece12"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2023-0393"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130014"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1947.148.2.327"},{"key":"refg5\/ref5","first-page":"S60","volume":"30","author":"Casellas D.","year":"1990","journal-title":"Kidney Int. 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