{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:13:27Z","timestamp":1792271607345,"version":"4.4.0"},"reference-count":47,"publisher":"Canadian Science Publishing","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p> The aim of the present study was to test the effects of different doses of anhydrous theacrine (3 and 6\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> of body mass) on 4 km cycling time trial performance. Nineteen (11 men and 8 women) cyclists (30.8\u00a0\u00b1\u00a010.0 years, 71.7\u00a0\u00b1\u00a011.8\u00a0kg, 170.1\u00a0\u00b1\u00a09.0\u00a0cm, and 17.0\u00a0\u00b1\u00a06.2% of body fat) completed three 4 km cycling time trials after ingesting either placebo, or 3 or 6\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> of body mass of theacrine. No significant differences ( p\u00a0&lt;\u00a00.05) were observed in time to cover the 4 km cycling time trial between the placebo, 3\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> of theacrine, and 6\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> of theacrine conditions. However, the intake of theacrine at the dose of 6\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> increased resting systolic and diastolic blood pressure ( p\u00a0&lt;\u00a00.05). Some side effects, such as gastrointestinal discomfort, perception of tachycardia, dizziness, headache, head pressure, hand tremor, and lack of disposition were reported after the ingestion of either 3 or 6\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> of body mass of theacrine. In conclusion, theacrine supplementation does not improve endurance performance and provokes side effects that might restrict its use as a supplement. <\/jats:p>","DOI":"10.1139\/apnm-2024-0442","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:33:09Z","timestamp":1744371189000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Different doses of theacrine do not improve 4 km cycling time trial performance"],"prefix":"10.1139","volume":"50","author":[{"given":"Victor","family":"Vieira-Cavalcante","sequence":"first","affiliation":[{"name":"Federal University of Technology Parana (GPPH-UTFPR)","place":["Curitiba, Brazil"]},{"name":"State University of Minas Gerais","place":["Passos, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Cezar","family":"Schamne","sequence":"additional","affiliation":[{"name":"Federal University of Technology Parana (GPPH-UTFPR)","place":["Curitiba, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felippi","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Federal University of Technology Parana (GPPH-UTFPR)","place":["Curitiba, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romulo","family":"Bertuzzi","sequence":"additional","affiliation":[{"name":"Federal University of Technology Parana (GPPH-UTFPR)","place":["Curitiba, Brazil"]},{"name":"University of S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Paola Trindade Rocha","family":"Pierucci","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Boari","sequence":"additional","affiliation":[{"name":"Federal University of ABC","place":["Santo Andre, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-5104","authenticated-orcid":false,"given":"Adriano Eduardo","family":"Lima-Silva","sequence":"additional","affiliation":[{"name":"Federal University of Technology Parana (GPPH-UTFPR)","place":["Curitiba, Brazil"]},{"name":"State University of Minas Gerais","place":["Passos, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-7851","authenticated-orcid":false,"given":"Renata Gon\u00e7alves","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Technology Parana (GPPH-UTFPR)","place":["Curitiba, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2011.03.009"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2016-0095"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2015.1120782"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-019-0287-6"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6973.170"},{"issue":"5","key":"refg6\/ref6","first-page":"377","volume":"14","author":"Borg G.A.","year":"1982","journal-title":"Med. 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