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It was the aim of this study to investigate the effects of ionomycin in osteoblatic MC3T3-E1 cells that are not attributable to its ionophoric properties. Thus, we have found that in contrast to A23187, ionomycin shows similar effects on prostaglandin E<jats:sub>2<\/jats:sub> formation as bradykinin and endothelin-1, being potentiated by extracellular nickel and inhibited by cholera toxin and pertussis toxin. Our data strongly suggest that inomycin, at least in part, exerts its effects via specific binding to a G-protein coupled receptor, thereby evoking downstream cellular events like arachidonate release with subsequent prostaglandin formation. <\/jats:p>","DOI":"10.1139\/bcb-2015-0148","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T22:45:00Z","timestamp":1455057900000},"page":"236-240","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ionomycin induces prostaglandin E<sub>2<\/sub> formation in murine osteoblastic MC3T3-E1 cells via mechanisms independent of its ionophoric nature"],"prefix":"10.1139","volume":"94","author":[{"given":"Hans J\u00f6rg","family":"Leis","sequence":"first","affiliation":[{"name":"University Hospital of Youth and Adolescence Medicine, Medical University of Graz, Research Unit of Analytical Mass Spectrometry, Cell Biology and Biochemistry of Inborn Errors of Metabolism, Auenbruggerplatz 34\/2, A-8036 Graz, Austria."},{"name":"University Hospital of Youth and Adolescence Medicine, Medical University of Graz, Research Unit of Analytical Mass Spectrometry, Cell Biology and Biochemistry of Inborn Errors of Metabolism, Auenbruggerplatz 34\/2, A-8036 Graz, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Windischhofer","sequence":"additional","affiliation":[{"name":"University Hospital of Youth and Adolescence Medicine, Medical University of Graz, Research Unit of Analytical Mass Spectrometry, Cell Biology and Biochemistry of Inborn Errors of Metabolism, Auenbruggerplatz 34\/2, A-8036 Graz, Austria."},{"name":"University Hospital of Youth and Adolescence Medicine, Medical University of Graz, Research Unit of Analytical Mass Spectrometry, Cell Biology and Biochemistry of Inborn Errors of Metabolism, Auenbruggerplatz 34\/2, A-8036 Graz, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.056010"},{"issue":"4","key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"C629","DOI":"10.1152\/ajpcell.1986.250.4.C629","volume":"250","author":"Erlij D.","year":"1986","journal-title":"Am. 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