{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:22:47Z","timestamp":1772781767607,"version":"3.50.1"},"reference-count":94,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p> A 22-year-old male suffering from abdominal pain, repeated diarrhea, and weight loss visited the Digestive Disease Department of Nagoya City University Hospital on 19 December 2011. He was hospitalized and diagnosed with Crohn\u2019s colitis. His Crohn\u2019s Disease Activity Index (CDAI) was 415. Treatment by granulocyte apheresis, mesalazine, and adalimumab was started. His CDAI was 314 on 30 December and 215 on 5 January. A colonoscopic examination on 19 January showed almost complete remission in the transverse colon and marked remission in the rectum. Mesalazine therapy was stopped on 28 February, and the patient was instructed to self-inject 40 mg of adalimumab every other week. His CDAI was 50 on 10 April, indicating clinical remission. His last self-injection of adalimumab was on 24 April 2012, and he started taking 1 g of bovine lactoferrin (bLF) daily. His CDAI was 35 on 8 January 2013. He continued taking 1 g of bLF daily without any other treatment for Crohn\u2019s disease. Laboratory blood tests on 7 September 2015 showed no sign of disease recurrence, and a colonoscopic examination on 23 October 2015 showed almost complete mucosal healing. This case indicates that ingestion of bLF to maintain Crohn\u2019s disease in a remissive state should be further explored. <\/jats:p>","DOI":"10.1139\/bcb-2016-0107","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T22:42:31Z","timestamp":1480545751000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Bovine lactoferrin and Crohn\u2019s disease: a case study"],"prefix":"10.1139","volume":"95","author":[{"given":"David B.","family":"Alexander","sequence":"first","affiliation":[{"name":"Nanotoxicology Project, Nagoya City University, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Iigo","sequence":"additional","affiliation":[{"name":"Nanotoxicology Project, Nagoya City University, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdelgied","sequence":"additional","affiliation":[{"name":"Nanotoxicology Project, Nagoya City University, Nagoya, Japan."},{"name":"Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan."},{"name":"Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tanida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Joh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Nanotoxicology Project, Nagoya City University, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4453"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1139\/o2012-013"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2014.06.028"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13039"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.08.013"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i5.1165"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199504000-00008"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nri2316"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.056"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.2.146"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-14-10"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90402-X"},{"issue":"4","key":"refg13\/ref13","first-page":"200","volume":"11","author":"Bresci G.","year":"1991","journal-title":"Int. J. Clin. Pharmacol. Res."},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198812000-00011"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308338"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.5.674"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.041"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00212.x"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307150"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2012.2701"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i11.2995"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006013422202"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706625104"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.4.485"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.051"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00590.x"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2012-5946"},{"issue":"2","key":"refg28\/ref28","first-page":"435","volume":"104","author":"Gendre J.P.","year":"1993","journal-title":"The Groupe d\u2019Etudes Therapeutiques des Affections Inflammatoires Digestives (GETAID). Gastroenterology"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.5499"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.4.493"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","unstructured":"G\u00fcnther, C., Josenhans, C., and Wehkamp, J. 2016. Crosstalk between microbiota, pathogens and the innate immune responses. Int. J. Med. Microbiol. 10.1016\/j.ijmm.2016.03.003.","DOI":"10.1016\/j.ijmm.2016.03.003"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08512-4"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01162.x"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9037-5"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-014-9747-2"},{"issue":"1","key":"refg36\/ref36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2036.1990.tb00449.x","volume":"4","author":"IMSG","year":"1990","journal-title":"International Mesalazine Study Group. Aliment. Pharmacol. Ther."},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05573.x"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-012-1030-9"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006451107"},{"issue":"5","key":"refg40\/ref40","first-page":"893","volume":"3","author":"Karagozian R.","year":"2007","journal-title":"Ther. Clin. Risk Manage."},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0208"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(98)00224-6"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9068-9_3. PMID:"},{"issue":"8","key":"refg44\/ref44","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1093\/jn\/131.8.2121","volume":"131","author":"Kuwata H.","year":"2001","journal-title":"J. Nutr."},{"issue":"5","key":"refg45\/ref45","first-page":"1647","volume":"102","author":"Landi B.","year":"1992","journal-title":"The Groupe d\u2019Etudes Therapeutiques des Affections Inflammatoires Digestives. Gastroenterology"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70420-2"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.031"},{"issue":"1","key":"refg48\/ref48","first-page":"69","volume":"18","author":"Lennard-Jones J.E.","year":"1977","journal-title":"A multicentre trial. Gut"},{"key":"refg49\/ref49","doi-asserted-by":"publisher","DOI":"10.4021\/jocmr499w"},{"key":"refg50\/ref50","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1632"},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01140.x"},{"key":"refg52\/ref52","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.09.034"},{"key":"refg53\/ref53","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.552"},{"issue":"2","key":"refg54\/ref54","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0016-5085(84)90409-8","volume":"86","author":"Malchow H.","year":"1984","journal-title":"Gastroenterology"},{"key":"refg55\/ref55","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8608877"},{"key":"refg56\/ref56","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000052"},{"key":"refg57\/ref57","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12160"},{"key":"refg58\/ref58","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.118646"},{"key":"refg59\/ref59","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509089276"},{"key":"refg60\/ref60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2002.tb02484.x"},{"key":"refg61\/ref61","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201773"},{"key":"refg62\/ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.11.026"},{"key":"refg63\/ref63","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.579"},{"issue":"2","key":"refg64\/ref64","first-page":"363","volume":"103","author":"Prantera C.","year":"1992","journal-title":"The Italian IBD Study Group. Gastroenterology"},{"key":"refg65\/ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.002"},{"key":"refg66\/ref66","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.014"},{"key":"refg67\/ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.08.011"},{"key":"refg68\/ref68","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.01.035"},{"key":"refg69\/ref69","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309333"},{"key":"refg70\/ref70","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.155812"},{"key":"refg71\/ref71","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20927"},{"key":"refg72\/ref72","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062897"},{"key":"refg73\/ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.09.002"},{"key":"refg74\/ref74","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.660541"},{"issue":"4","key":"refg75\/ref75","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0016-5085(79)90385-8","volume":"77","author":"Summers R.W.","year":"1979","journal-title":"Gastroenterology"},{"issue":"4","key":"refg76\/ref76","first-page":"1069","volume":"112","author":"Sutherland L.R.","year":"1997","journal-title":"The Canadian Mesalamine for Remission of Crohn\u2019s Disease Study Group. Gastroenterology"},{"issue":"6","key":"refg77\/ref77","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2036.1995.tb00438.x","volume":"9","author":"Thomson A.B.","year":"1995","journal-title":"Aliment. Pharmacol. Ther."},{"key":"refg78\/ref78","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00331.2001"},{"key":"refg79\/ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.08.028"},{"issue":"9","key":"refg80\/ref80","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1093\/jn\/132.9.2597","volume":"132","author":"Troost F.J.","year":"2002","journal-title":"J. Nutr."},{"key":"refg81\/ref81","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000196"},{"key":"refg82\/ref82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00274.x"},{"key":"refg83\/ref83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01944.x"},{"key":"refg84\/ref84","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.9.5398"},{"key":"refg85\/ref85","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3180308d8e"},{"key":"refg86\/ref86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04446.x"},{"key":"refg87\/ref87","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1326.030"},{"key":"refg88\/ref88","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0904543"},{"key":"refg89\/ref89","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.48"},{"key":"refg90\/ref90","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000092107"},{"key":"refg91\/ref91","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3419-5"},{"issue":"7731","key":"refg92\/ref92","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0140-6736(71)90268-6","volume":"2","author":"Willoughby J.M.","year":"1971","journal-title":"Lancet"},{"key":"refg93\/ref93","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i4.520"},{"key":"refg94\/ref94","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20238"}],"container-title":["Biochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/bcb-2016-0107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/bcb-2016-0107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:14:26Z","timestamp":1751480066000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/bcb-2016-0107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":94,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1139\/bcb-2016-0107"],"URL":"https:\/\/doi.org\/10.1139\/bcb-2016-0107","relation":{},"ISSN":["0829-8211","1208-6002"],"issn-type":[{"value":"0829-8211","type":"print"},{"value":"1208-6002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"2016-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}