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While the classical model associated with MeCP2 function suggests its role in gene suppression via recruitment of co-repressor complexes and histone deacetylases to methylated CpG-sites, recent discoveries have brought to light its role in transcription activation, modulation of RNA splicing, and chromatin compaction. Various post-translational modifications (PTMs) of MeCP2 further increase its functional versatility. Involvement of MeCP2 in pathologies other than RTT, such as tumorigenesis however, remains poorly explored and understood. This review provides a survey of the literature implicating MeCP2 in breast, colon and prostate cancer.<\/jats:p>","DOI":"10.1139\/bcb-2016-0154","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T17:35:23Z","timestamp":1478799323000},"page":"368-378","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Functional assessment of MeCP2 in Rett syndrome and cancers of breast, colon, and prostate"],"prefix":"10.1139","volume":"95","author":[{"given":"Somnath","family":"Pandey","sequence":"first","affiliation":[{"name":"Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA."},{"name":"Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Pruitt","sequence":"additional","affiliation":[{"name":"Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA."},{"name":"Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2015-0038"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700855200"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm599"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2348-7"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.03.004"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-13-19"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.038"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg604"},{"key":"refg10\/ref10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fncel.2014.00236","volume":"8","author":"Bellini E.","year":"2014","journal-title":"Front. 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