{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:37:30Z","timestamp":1770824250984,"version":"3.50.1"},"reference-count":35,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p> Although genetics plays an essential role in the pathogenesis of vitiligo, vitiligo pathogenesis is still unclear. Our aim was to investigate the role of IFN-\u03b3 expression and polymorphism in vitiligo susceptibility and whether intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor (TNF)-\u03b1, and TNF-\u03b2 play a role in vitiligo pathogenesis as important inflammatory parameters. Eighty-five patients with vitiligo and 90 controls were investigated for IFN-\u03b3 gene expression by quantitative real-time PCR and genotyped for IFN-\u03b3 +874T\/A (rs2430561) and IFN-\u03b3 +2109A\/G (rs1861494) gene polymorphisms by sequence-specific primer (SSP)-PCR and PCR-restriction fragment length polymorphism (RFLP), respectively. Serum levels of inflammatory parameters were measured using ELISA. Frequencies of the +874 TT genotype and T allele were significantly higher in patients with active vitiligo than in stable patients (P = 0.01 and 0.03, respectively). Calculation of odds ratio suggested a 1.7-fold increased risk of vitiligo in individuals having the TA haplotype. We observed overexpression of IFN-\u03b3 mRNA with elevated serum levels of IFN-\u03b3, ICAM-1, TNF-\u03b1, and TNF-\u03b2 in patients with vitiligo when compared with the control group (P = 0.001, for all). In addition, these levels were elevated in patients with active vitiligo compared with stable patients with vitiligo (P = 0.008, 0.006, 0.01, 0.01, and 0.03, respectively), which suggests the involvement of these cytokines in disease activity. In conclusion, IFN-\u03b3 is a promising immunological marker in vitiligo pathogenesis. <\/jats:p>","DOI":"10.1139\/bcb-2016-0228","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T22:35:05Z","timestamp":1489012505000},"page":"474-481","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Genetic variants of interferon-gamma and its mRNA expression and inflammatory parameters in the pathogenesis of vitiligo"],"prefix":"10.1139","volume":"95","author":[{"given":"Rehab A.","family":"Karam","sequence":"first","affiliation":[{"name":"Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidy E.","family":"Zidan","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed H.","family":"Khater","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1994.35.4.404"},{"key":"refg2\/ref2","first-page":"97","volume":"23","author":"Ali R.","year":"2010","journal-title":"Pak. 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