{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:16:59Z","timestamp":1767093419090,"version":"3.41.0"},"reference-count":77,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p> Veno-occlusive disease is an important pattern of hepatotoxicity associated with antineoplastic drugs. The study investigated the possible therapeutic effects of RHS nanoparticles combined with a PDGF on veno-occlusive disease (VOD) in liver elicited in rats with DAC. In this work, nanosilica (SiO<jats:sub>2<\/jats:sub>) was successfully prepared from rice husk, and its physicochemical characteristics were investigated using EDX, XRD, N<jats:sub>2<\/jats:sub> adsorption\u2013desorption isotherm, SEM, and TEM. Forty-eight male Sprague\u2013Dawely rats were distributed into 6 groups, with 8 rats in each. The first group served as the control. In the second group, animals were infused with DAC (0.015 mg\/kg; 1\u20133 days) by intraperitoneal injection (i.p.). In the third group, rats were injected i.p. with DAC, and then at 24 h following the last dose of DAC, received nano-RHS incorporated with PDGF twice a week for 4 weeks. In the fourth group, normal animals were injected with RHS. In the fifth group, normal rats received PDGF, and in the sixth group, normal rats received nano-RHS combined with PDGF. The prepared nanosilica showed type II adsorption isotherm characteristic for mesoporous materials with a specific surface area of 236 m<jats:sup>2<\/jats:sup>\/g. TEM imaging confirmed the production of nanoparticles via the followed preparation procedure. Radical scavenging potential for nano-RHS was determined using two different in-vitro assays: DPPH, and ABTS radicals. The results of this work show that administration of nano-RHS combined with PDGF significantly reversed the oxidative stress effects of DAC as evidenced by a decrease in liver function. It can be concluded that the nano-RHS combined with PDGF is useful in preventing oxidative stress and hepatic VOD induced by chemotherapy such as DAC. <\/jats:p>","DOI":"10.1139\/bcb-2017-0248","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T22:36:10Z","timestamp":1515105370000},"page":"682-694","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the therapeutic effects of rice husk nanosilica combined with platelet-derived growth factor in hepatic veno-occlusive disease"],"prefix":"10.1139","volume":"96","author":[{"given":"Eithar K.","family":"AL-Adham","sequence":"first","affiliation":[{"name":"Department of Radioisotopes, Nuclear Research Centre, Atomic Energy Authority, Giza, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal I.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Radioisotopes, Nuclear Research Centre, Atomic Energy Authority, Giza, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Shebl","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Hazem","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2010.02.055"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cattod.2012.04.056"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2013.05.066"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cemconres.2014.04.001"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clay.2012.02.018"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000101796"},{"key":"refg7\/ref7","unstructured":"Bancroft, J.D., and Stevens, A. 1996. 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