{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:43Z","timestamp":1787017123302,"version":"build-2736575974"},"reference-count":39,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Myocardial ischemia\u2013reperfusion injury (MIRI) is the leading cause of the poor prognosis for patients undergoing clinical cardiac surgery. Micro-RNAs are involved in MIRI; however, the effect of miR-760 on MIRI and the molecular mechanisms behind it have not yet been described. For our in-vivo experiments, 20 rats were randomly distributed between 2 groups (n = 10): the sham-treatment group and the ischemia\u2013reperfusion (I\/R) group. For our in-vitro experiments, H9C2 cells were subjected to hypoxia for 6 h, and then reoxygenated to establish an hypoxia\u2013reoxygenation (H\/R) model. High expression levels of of miR-760 were observed in the rats subjected to MIRI and the H9C2 cells subjected to H\/R. Further, the levels of lactate dehydrogenase (LDH) and malonaldehyde (MDA) were increased, and the size of the myocardial infarct was notably greater in the rats subjected to MIRI, suggesting that miR-760 worsens the effects of MIRI. The inhibitory effects from NaHS on apoptosis were enhanced, as were the expression levels of cleaved caspase 3 and cleaved PARP in H9C2 cells exposed to H\/R, and with low-expression levels of miR-760. TargetScan and dual luciferase reporter assays further confirmed the targeted relationship between dual-specificity protein phosphatase (DUSP1) and miR-760. Additionally, miR-760 overexpression and H\/R treatment of H9C2 cells inhibited the expression of DUSP1, which further promoted apoptosis. Furthermore, DUSP1 enhanced the anti-apoptotic effects of NaHS in rats subjected to MIRI. Taken together, these findings suggest that miR-760 inhibits the protective effect of NaHS against MIRI.<\/jats:p>","DOI":"10.1139\/bcb-2019-0310","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T17:36:17Z","timestamp":1583948177000},"page":"378-385","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["MicroRNA-760-mediated low expression of DUSP1 impedes the protective effect of NaHS on myocardial ischemia\u2013reperfusion injury"],"prefix":"10.1139","volume":"98","author":[{"given":"Lin","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hebei Medical University, Shijiazhuang City, Hebei Province 050011, China."},{"name":"Department of Cardiology, First Hospital of Qinhuangdao, Qinhuangdao City, Hebei Province 066000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, First Hospital of Qinhuangdao, Qinhuangdao City, Hebei Province 066000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Hospital of Qinhuangdao, Qinhuangdao City, Hebei Province 066000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hebei Medical University, Shijiazhuang City, Hebei Province 050011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm.2018.03.3181"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153035"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.aogh.2016.02.002"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201908_18559"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.05.020"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201907_18310"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-6260-6_6"},{"issue":"23","key":"refg8\/ref8","first-page":"5002","volume":"20","author":"Hu S.H.","year":"2016","journal-title":"Eur. 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