{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:19:58Z","timestamp":1764937198345,"version":"3.41.0"},"reference-count":38,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p> Results from previous studies have suggested that supplemental bovine lactoferrin (BLF) given to preterm infants (&lt;32\u00a0weeks gestation) reduces late-onset sepsis (LOS) and necrotising enterocolitis (NEC). The Enteral Lactoferrin in Neonates (ELFIN) study, performed in the UK, aimed to further address this issue with a well powered double-blind placebo controlled trial of &gt;2200 preterm infants. The results from ELFIN did not demonstrate a reduction in LOS or NEC, or several other clinically important measures. Of the 1093 infants, 316 (29%) in the intervention group developed late-onset sepsis versus 334 (31%) of 1089 in the control group, with an adjusted risk ratio of 0.95 (95%\u00a0CI = 0.86\u20131.04; p\u00a0= 0.233). Reasons for the differences in ELFIN trial results and other studies may include population differences, the routine use of antifungal prophylaxis in the UK, timing of administration of the lactoferrin in relation to disease onset, or specific properties of the lactoferrin used in the different trials. The UK National Institutes for Health Research funded \u201cMechanisms Affecting the Guts of Preterm Infants in Enteral feeding trials\u201d (MAGPIE) study is further exploring the use of lactoferrin, and the results should be available soon. <\/jats:p>","DOI":"10.1139\/bcb-2020-0073","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T21:37:40Z","timestamp":1598218660000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["ELFIN, the United Kingdom preterm lactoferrin trial: interpretation and future questions"],"prefix":"10.1139","volume":"99","author":[{"given":"Janet Elizabeth","family":"Berrington","sequence":"first","affiliation":[{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, and Translational and Clinical Medicine, Newcastle University, Newcastle, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"McGuire","sequence":"additional","affiliation":[{"name":"Centre for Reviews and Dissemination, University of York, York YO10 5DD, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas David","family":"Embleton","sequence":"additional","affiliation":[{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, and Population Health Sciences, Newcastle University, Newcastle, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816654"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1371704"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.24"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.06.046"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e3180332c8d"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jmicro\/52.2.207"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.02.072"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.5.G1140"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000488927"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2017.00014"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.064113-0"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.018119"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32221-9"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2008.05.015"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmv044"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.07.004"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.02.071"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.19.1.12.5342"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1080\/10495398.2017.1313269"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2013.811927"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-014-9762-33"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2016.03.020"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000593"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007137.pub5"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal. pone.0171477"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-48-6-541"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2009.01.003"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.196568"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1515\/bc.2008.116"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.04.084"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.02.074"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-098038"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.03.032"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5372-0"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194707"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.10.030"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13108"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201819"}],"container-title":["Biochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/bcb-2020-0073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/bcb-2020-0073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:03:51Z","timestamp":1751479431000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/bcb-2020-0073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1139\/bcb-2020-0073"],"URL":"https:\/\/doi.org\/10.1139\/bcb-2020-0073","relation":{},"ISSN":["0829-8211","1208-6002"],"issn-type":[{"type":"print","value":"0829-8211"},{"type":"electronic","value":"1208-6002"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}