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Cell Biol."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p> Since our previous results suggest that lactoferrin (LF) might have roles in the reproductive process and that its levels might change in the female tract as a response to various factors, the aim of this investigation was to assess whether LF levels in cervical secretions correlate with reproductive parameters from in\u00a0vitro fertilization (IVF) patients. Cervical fluid samples were obtained from 34 women under 40\u00a0years old enrolled for assisted reproduction techniques, and LF concentration was measured. The mean total protein concentration in all cervical fluid samples was 842.8\u00a0\u00b1\u2009116.9\u00a0\u00b5g\/mL. The mean concentration of LF was 0.73\u00a0\u00b1\u20090.06\u00a0ng LF\/\u00b5g of total proteins. We observed that higher LF levels in cervical fluid correlated with lower IVF rates when all patients were analyzed; this negative correlation was also sustained when only patients \u226535 years were studied. The mean LF concentration in cervical fluid was significantly lower among patients with normal IVF rates than in those with values 50% or less. Using a LF cutoff value of 0.83\u00a0ng\/\u03bcg of total proteins, the study revealed a significant association between the LF levels below 0.83\u00a0ng\/\u00b5g of total proteins and IVF rates above 50%. LF levels in cervical mucus could potentially be used as a marker of fertilization outcome. <\/jats:p>","DOI":"10.1139\/bcb-2020-0098","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T21:34:25Z","timestamp":1590960865000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients \u2014 correlation with IVF parameters"],"prefix":"10.1139","volume":"99","author":[{"given":"Estefan\u00eda","family":"Massa","sequence":"first","affiliation":[{"name":"Area of Clinical Biochemistry, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Suipacha 531, S2000 Rosario, Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabi\u00e1n","family":"Pelusa","sequence":"additional","affiliation":[{"name":"Area of Clinical Biochemistry, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Suipacha 531, S2000 Rosario, Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustina","family":"Lo Celso","sequence":"additional","affiliation":[{"name":"Area of Clinical Biochemistry, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Suipacha 531, S2000 Rosario, Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Madariaga","sequence":"additional","affiliation":[{"name":"Area of Morphology, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Suipacha 531, S2000 Rosario, Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Filocco","sequence":"additional","affiliation":[{"name":"PROAR \u2014 Programa de Asistencia Reproductiva de Rosario, G\u00fcemes 2349, S2000 Rosario, Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Morente","sequence":"additional","affiliation":[{"name":"PROAR \u2014 Programa de Asistencia Reproductiva de Rosario, G\u00fcemes 2349, S2000 Rosario, Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Ghersevich","sequence":"additional","affiliation":[{"name":"Area of Clinical Biochemistry, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Suipacha 531, S2000 Rosario, Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-018-9734-0"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.01.030"},{"issue":"4","key":"refg3\/ref3","first-page":"318","volume":"46","author":"Chimura T.","year":"1993","journal-title":"Jpn. 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