{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:22:56Z","timestamp":1783984976921,"version":"3.55.0"},"reference-count":54,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p> The discovery of new pharmacological agents is needed to control the progression of osteoarthritis (OA), characterized by joint cartilage damage. Human OA chondrocyte (OAC) cultures were either applied to S-allylcysteine (SAC), a sulfur-containing amino acid derivative, or colchicine, an ancient anti-inflammatory therapeutic, for 24 h. SAC or colchicine did not change viability at 1 nM\u201310 \u00b5M but inhibited p-JNK\/pan-JNK. While SAC seems to be more effective, both agents inhibited reactive oxygen species (ROS), 3-nitrotyrosine (3-NT), lipid hydroperoxides (LPO), advanced lipoxidation end-products (ALEs as 4-hydroxy-2-nonenal, HNE), advanced glycation end-products (AGEs), and increased glutathione peroxidase (GPx) and type-II-collagen (COL2). IL-1\u03b2, IL-6, and osteopontin (OPN) were more strongly inhibited by SAC than by colchicine. In contrast, TNF-\u03b1 was inhibited only by SAC, and COX2 was only inhibited by colchicine. Casp-1\/ICE, GM-CSF, receptor for advanced glycation end-products (RAGE), and toll-like receptors (TLR4) were inhibited by both agents, but bone morphogenetic protein 7 (BMP7) was partially inhibited by SAC and induced by colchicine. Nuclear factor erythroid 2-related factor 2 (Nrf2) was induced by SAC; in contrast, it was inhibited by colchicine. Although they exert opposite effects on TNF-\u03b1, COX2, BMP7, and Nrf2, SAC and colchicine exhibit anti-osteoarthritic properties in OAC by modulating redox-sensitive inflammatory signaling. <\/jats:p>","DOI":"10.1139\/bcb-2021-0004","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T21:38:55Z","timestamp":1619818735000},"page":"645-654","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>S<\/i>-allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine"],"prefix":"10.1139","volume":"99","author":[{"given":"Zubeyir","family":"Elmazoglu","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology, Cellular Stress Response and Signal Transduction Research Laboratory, Faculty of Medicine, Gazi University, Be\u015fevler, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Ayd\u0131n Bek","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Cellular Stress Response and Signal Transduction Research Laboratory, Faculty of Medicine, Gazi University, Be\u015fevler, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanem Gulistan","family":"Sar\u0131ba\u015f","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, K\u0131rsehir Ahi Evran University, Ba\u011fba\u015f\u0131 Campus, K\u0131r\u015fehir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candan","family":"\u00d6zo\u011ful","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Kyrenia University, Kyrenia, Cyprus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Goker","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Gazi University, Be\u015fevler, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berivan","family":"Bitik","sequence":"additional","affiliation":[{"name":"Ankara Research and Education Hospital, Alt\u0131nda\u011f, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem Nuri","family":"Aktekin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Faculty of Medicine, Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7imen","family":"Karasu","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Cellular Stress Response and Signal Transduction Research Laboratory, Faculty of Medicine, Gazi University, Be\u015fevler, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2020-0230"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.3390\/biology9040065"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2018.1445581"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2008.00625.x"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22275.1"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1732924"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122146"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066611"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/595273"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-eular.7038"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-eular.6046"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1002\/term.3138"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.02.167"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.4236\/ijcm.2012.35071"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.09.025"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3784"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1177\/0885328210374671"},{"issue":"120","key":"refg18\/ref18","first-page":"124","volume":"37","author":"Ghouri A.","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1002\/art.40700"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.1024110"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-020-00220-1"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-013-1628-4"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.200"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.07.011"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1560::AID-ANR21>3.0.CO;2-S"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.013"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24131"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.01.021"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.01.003"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.025"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.06.013"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.01.026"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1070-6"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6345656"},{"issue":"120","key":"refg36\/ref36","first-page":"48","volume":"37","author":"Millerand M.","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3075293"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3481-7"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1002\/art.21559"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19930-w"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.10.7.1207"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-020-00260-7"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.02.781"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-020-09664-6"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103757"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.11.002"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M907604199"},{"key":"refg48\/ref48","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.8380"},{"key":"refg49\/ref49","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459"},{"key":"refg50\/ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108610"},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2020.1778679"},{"key":"refg52\/ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00739-7"},{"key":"refg53\/ref53","doi-asserted-by":"publisher","DOI":"10.15386\/mpr-1422"},{"key":"refg150\/ref150","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.12.013"}],"container-title":["Biochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/bcb-2021-0004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/bcb-2021-0004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:02:20Z","timestamp":1751479340000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/bcb-2021-0004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1139\/bcb-2021-0004"],"URL":"https:\/\/doi.org\/10.1139\/bcb-2021-0004","relation":{},"ISSN":["0829-8211","1208-6002"],"issn-type":[{"value":"0829-8211","type":"print"},{"value":"1208-6002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2021-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}