{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:44:19Z","timestamp":1792449859109,"version":"4.5.0"},"reference-count":0,"publisher":"Canadian Science Publishing","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"abstract":"<jats:p> Lactoferrin (Lf), we have previously shown, has therapeutic potential in the field of skeletal regenerative medicine demonstrating its potent stimulating effects on bone growth. Recently, we have identified bovine lactoferrin (bLf) as a factor that also enhances antibiotic killing of Staphylococcus aureus (S. aureus). Biofilms are associated with around 65% of all infections and 80% of chronic infections. One feature of biofilm infection is tolerance to antibiotics due to the survival of a subpopulation of biofilm bacteria, where laboratory tests on planktonic cells indicate susceptibility. Tolerance is seen in bone infections of osteomyelitis and prosthetic joints, where methicillin-susceptible S. aureus (MSSA) strains predominate, but where treatments with the frontline penicillinase-resistant antibiotic cefazolin (CEF) can be ineffective. In vitro-grown biofilms of MSSA are 1000-fold more tolerant to CEF but can be eradicated by CEF at 10x minimal inhibitory concentration in the presence of bLf.\r Bone infection can impede blood circulation within the bone, leading to bone death. Lf as a potent stimulator of bone growth adds to its appeal as a treatment for bone infections.\r <\/jats:p>","DOI":"10.1139\/bcb-2024-0101","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T21:34:21Z","timestamp":1744839261000},"source":"Crossref","is-referenced-by-count":2,"title":["LACTOFERRIN ENHANCES THE ANTIBIOTIC TREATMENT OF STAPHYLOCOCCUS AUREUS IN BONE INFECTION"],"prefix":"10.1139","author":[{"given":"Jillian","family":"Cornish","sequence":"first","affiliation":[{"name":"University of Auckland, Department of Medicine, Auckland, New Zealand, ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reece","family":"Joseph","sequence":"additional","affiliation":[{"name":"University of Auckland, Department of Medicine, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-ming","family":"Lin","sequence":"additional","affiliation":[{"name":"University of Auckland, Department of Medicine, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Irwin","sequence":"additional","affiliation":[{"name":"Bioprocess Technical operations, RedRock, Denver, United States;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janesha","family":"Perera","sequence":"additional","affiliation":[{"name":"University of Auckland, Department of Molecular Medicine and Pathology, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Callon","sequence":"additional","affiliation":[{"name":"University of Auckland, Department of Medicine, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagir","family":"Hussan","sequence":"additional","affiliation":[{"name":"University of Auckland, Bioengineering, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Wen","sequence":"additional","affiliation":[{"name":"University of Auckland, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haemish","family":"Crawford","sequence":"additional","affiliation":[{"name":"University of Auckland, Department of Surgery, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brya","family":"Matthews","sequence":"additional","affiliation":[{"name":"University of Auckland, Department of Medicine, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Ashton","sequence":"additional","affiliation":[{"name":"University of Utah, Department of Orthopaedics, Salt Lake City, Utah, United States;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Utah, Department of Orthopaedics, Salt Lake City, United States"},{"name":"University of Utah, Department of Biomedical Engineering, Salt Lake City, Utah, United States"},{"name":"University of Utah, Department of Pathology, Salt Lake City, Utah, United States"},{"name":"Uniformed Services University of the Health Sciences, Department of Physical Medicine and Rehabilitation, Bethesda, United States;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Baker","sequence":"additional","affiliation":[{"name":"University of Auckland, Auckland, New Zealand, ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Baker","sequence":"additional","affiliation":[{"name":"University of Auckland - City Campus, Biological Sciences, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Swift","sequence":"additional","affiliation":[{"name":"University of Auckland, Department of Molecular Medicine and Pathology, Auckland, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","published-online":{"date-parts":[[2025,4,16]]},"container-title":["Biochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/bcb-2024-0101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T10:58:18Z","timestamp":1745492298000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/bcb-2024-0101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":0,"alternative-id":["10.1139\/bcb-2024-0101"],"URL":"https:\/\/doi.org\/10.1139\/bcb-2024-0101","relation":{},"ISSN":["0829-8211","1208-6002"],"issn-type":[{"value":"0829-8211","type":"print"},{"value":"1208-6002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"article-number":"bcb-2024-0101"}}