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Cell Biol."],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p> Inflammatory bowel disease is a gut\u2013brain axis disorder that comprises chronic inflammatory conditions affecting the gastrointestinal tract, where alterations in the mood of patients are common. Gut\u2013brain axis is a bidirectional communication that link gut and brain. The close association between inflammatory bowel disease and neuroinflammation has far-reaching implications, as is increasingly recognized as a contributing factor to neuropsychiatric and neurodegenerative diseases. The increasing prevalence and high economic cost, together with the loss of life quality of people suffering from these diseases, point to the need to find alternatives to alleviate them. Exploring new therapeutic avenues prompts us to consider the potential benefits of milk fractions, taking advantage of the use of dairy by-products, such as whey and buttermilk. This study examines the impact of cow\u2019s whey- and buttermilk-based formulas supplemented with bovine lactoferrin and milk fat globule membrane on the expression of cytokines, as well as on the components of immune and serotonergic system of the brain in a murine model of dextran sodium sulfate-induced colitis. Our results show the potential of these dairy by-products, especially whey, as functional foods in ameliorating neuroinflammation and safeguarding the central nervous system function amid the neurological complications induced or concomitant with intestinal inflammatory processes. <\/jats:p>","DOI":"10.1139\/bcb-2024-0153","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T17:33:16Z","timestamp":1727803996000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Neuroprotective effects of whey and buttermilk-based formulas on a DSS-induced colitis murine model"],"prefix":"10.1139","volume":"103","author":[{"given":"Berta","family":"Buey","sequence":"first","affiliation":[{"name":"Universidad de Zaragoza","place":["Zaragoza, Spain"]},{"name":"Instituto Agroalimentario de Arag\u00f3n (IA2), Universidad de Zaragoza-CITA","place":["Zaragoza, 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