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Cell Biol."],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p> Our previous study showed antitumor activity of the complex formed by iron-free recombinant human lactoferrin (apo-recHLF) and oleic acid (OA) (1:8 molar ratio) in a model of murine hepatoma 22a inoculated to C3HA mice. Taken alone, apo-recHLF was less efficient; i.e., the tumor growth index was 0.14 for recHLF-8OA and 0.63 for recHLF as compared with 1.0 in the control animals. In the present study, we evaluated antitumor activity of iron-saturated recHLF per se and of the complexes formed by OA with apo-recHLF and holo-recHLF. Balb\/c mice with solid myeloma Sp2\/0 were subjected to the 10-day treatment with daily intraperitoneal (i\/p) injections of 10\u00a0mg iron-saturated recHLF with OA (1:8) per animal (0.4\u00a0g\/kg). In 15 days, the tumor growth was substantially inhibited. Mean tumor mass was 93% lower as compared with the control value ( p\u00a0&lt;\u00a00.01). 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