{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:43:44Z","timestamp":1791607424858,"version":"4.3.4"},"reference-count":56,"publisher":"Canadian Science Publishing","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>Rosacea is a chronic inflammatory skin condition marked by excessive M1 macrophage polarization and angiogenesis, resulting in erythema and tissue inflammation. Despite available treatments, many patients experience recurrent flare-ups. This study explores chelerythrine, a bioactive component of Phellodendri Chinensis Cortex, for its therapeutic potential in rosacea through modulation of NF-\u03baB, p38 MAPK, and STAT3 signaling, inflammation, and vascular regulation. Using an LL-37-induced rosacea-like mouse model, THP-1-derived M1 macrophages and human umbilical vein endothelial cells (HUVECs), chelerythrine's effects on macrophage polarization, cytokine expression, angiogenesis, and pathway activation of NF-\u03baB, p38 MAPK, and STAT3 were evaluated. Chelerythrine significantly reduced epidermal thickness, inflammatory cell infiltration, and pro-inflammatory markers (TNF-\u03b1 and IL-1\u03b2). It inhibited NF-\u03baB, p38 MAPK, and STAT3 activation and decreased M1 polarization markers, shifting towards an anti-inflammatory profile. Furthermore, chelerythrine reduced vascular density and VEGF expression, impairing angiogenesis-related behaviors in HUVECs. These findings suggest that chelerythrine holds promise as a treatment for rosacea by mitigating inflammation and angiogenesis through targeted multiple pathways and macrophage modulation.<\/jats:p>","DOI":"10.1139\/bcb-2025-0124","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T21:35:42Z","timestamp":1757021742000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Chelerythrine alleviates inflammation and angiogenesis in a mouse rosacea model via suppressing the NF-\u03baB\/p38 MAPK\/STAT3 pathways"],"prefix":"10.1139","volume":"104","author":[{"given":"Rong","family":"Zhou","sequence":"first","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Yang","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Wang","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Wang","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijunzi","family":"Luo","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Huang","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-ning","family":"Yan","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Long","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-2995","authenticated-orcid":false,"given":"Haizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/abd1806-4841.20163541","volume":"91","author":"Addor F.A.","year":"2016","journal-title":"An. 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