{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:30:53Z","timestamp":1771540253432,"version":"3.50.1"},"reference-count":21,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Vibrio cholerae is the causative agent of the devastating diarrheal disease cholera. A number of regulatory pathways are involved in V. cholerae pathogenesis and antibiotic resistance. For example, there are over 40 LysR-family proteins in the V. cholerae genome, but most of their functions are unknown. In this study, we examine the role of VC2323 (TehA<jats:sub>Vc<\/jats:sub>) and its divergently transcribed LysR-family regulator VC2324 (TehR<jats:sub>Vc<\/jats:sub>) in V. cholerae pathogenesis. We found that in V. cholerae C6706, the expression of tehA<jats:sub>Vc<\/jats:sub>is dependent on TehR<jats:sub>Vc<\/jats:sub>. VC2323 (TehA<jats:sub>Vc<\/jats:sub>), homologous to the Escherichia coli tellurite resistance protein (TehA<jats:sub>Ec<\/jats:sub>), differs from TehA<jats:sub>Ec<\/jats:sub>in that TehA<jats:sub>Vc<\/jats:sub>has no noticeable role in tellurite resistance but instead contributes to chloramphenicol resistance. Interestingly, both tehA<jats:sub>Vc<\/jats:sub>and tehR<jats:sub>Vc<\/jats:sub>mutants were defective in colonization of infant mice. Though the expression of a key virulence gene tcpA was not affected in either of these mutants, tehA<jats:sub>Vc<\/jats:sub>mutants failed to attach to mouse intestinal surfaces in the presence of crude bile, suggesting a new role of the TehA<jats:sub>Vc<\/jats:sub>\u2013TehR<jats:sub>Vc<\/jats:sub>pair in V. cholerae pathogenesis.<\/jats:p>","DOI":"10.1139\/cjm-2012-0673","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T14:57:09Z","timestamp":1357225029000},"page":"136-139","source":"Crossref","is-referenced-by-count":8,"title":["Role of a TehA homolog in<i>Vibrio cholerae<\/i>C6706 antibiotic resistance and intestinal colonization"],"prefix":"10.1139","volume":"59","author":[{"given":"Bin","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Microbiology, Nanjing Agricultural University, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nanjing Agricultural University, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Katzianer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nanjing Agricultural University, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nanjing Agricultural University, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengtao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nanjing Agricultural University, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nanjing Agricultural University, China; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.3.874-881.2006"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00236-12"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nature09487"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.10.008"},{"issue":"4","key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/MMBR.62.4.1301-1314.1998","volume":"62","author":"Faruque S.M.","year":"1998","journal-title":"Microbiol. 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