{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:17:23Z","timestamp":1773922643050,"version":"3.50.1"},"reference-count":32,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p> One hundred fifty-three Shigella isolates were examined for multiple antibiotic resistance phenotypes and prevalence of class 1 and class 2 integron sequences. The gene cassettes dfrA17-aadA5, dfrA12-orfF-aadA2, and arr-3-aacA4 were found in typical class 1 integrons. The gene cassettes bla<jats:sub>OXA-1<\/jats:sub>-aadA1 and dfrA1-sat1-aadA1 were detected in atypical class 1 integrons and in class 2 integrons, respectively. This is the first report of arr-3-aacA4 cassette detected in typical class 1 integrons among Shigella isolates. Rates of antibiotic resistance were different between integron-positive and integron-negative strains (P &lt; 0.05), and all integron-positive isolates were resistant to at least 3 different antimicrobial agents. Typical class 1 integron-positive isolates showed higher resistance rates to cefotaxime and ciprofloxacin than did integron-negative ones (P &lt; 0.05). Typical class 1 integrons and \u03b2-lactamase genes were found in conjugative plasmids, otherwise class 2 and atypical class 1 integrons were located on chromosome. This study demonstrated the wide distribution of class 1 integrons in Shigella spp., which may lead resistance to cefotaxime and ciprofloxacin in China. <\/jats:p>","DOI":"10.1139\/cjm-2013-0893","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T18:59:37Z","timestamp":1394218777000},"page":"237-242","source":"Crossref","is-referenced-by-count":11,"title":["Antimicrobial resistance patterns and characterization of integrons in clinical isolates of <i>Shigella<\/i> from China"],"prefix":"10.1139","volume":"60","author":[{"given":"Haifei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yachao","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Center Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Institute of Bacterial Resistance, Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Anhui Center for Surveillance of Bacterial Resistance, Hefei, Anhui, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Institute of Bacterial Resistance, Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Anhui Center for Surveillance of Bacterial Resistance, Hefei, Anhui, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Institute of Bacterial Resistance, Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Anhui Center for Surveillance of Bacterial Resistance, Hefei, Anhui, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Institute of Bacterial Resistance, Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Anhui Center for Surveillance of Bacterial Resistance, Hefei, Anhui, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Institute of Bacterial Resistance, Anhui Medical University, Hefei, Anhui, People\u2019s Republic of China."},{"name":"Anhui Center for Surveillance of Bacterial Resistance, Hefei, Anhui, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46725-0"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.5.1055"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm204"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00997-08"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.06.005"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.022517-0"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47322-0"},{"key":"refg8\/ref8","unstructured":"Clinical and Laboratory Standards Institute. 2012. 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