{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:00:50Z","timestamp":1769068850036,"version":"3.49.0"},"reference-count":30,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p> Here we report the production of the cyclic macrotetrolide nonactin from the fermentation culture of Streptomyces griseus subsp. griseus. Nonactin is a member of a family of naturally occurring cyclic ionophores known as the macrotetrolide antibiotics. Our fermentation procedure of Streptomyces griseus was performed at 30 \u00b0C and 200 rev\u00b7min<jats:sup>\u22121<\/jats:sup> for 5 days on a rotary shaker. Diaion HP-20 and Amberlite XAD-16 were added to the fermentation medium. Isolated yield of nonactin was up to 80 mg\u00b7L<jats:sup>\u22121<\/jats:sup> using our methodology. Nonactin is commonly known as an ammonium ionophore and also exhibits antibacterial, antiviral, and antitumor activities. It is also widely used for the preparation of ion-selective electrodes and sensors. Chemical synthesis of nonactin has been achieved by some groups; however, overall yields are very low, making efficient biosynthesis an attractive means of production. <\/jats:p>","DOI":"10.1139\/cjm-2016-0248","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T23:52:49Z","timestamp":1465602769000},"page":"711-714","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficient production of nonactin by <i>Streptomyces griseus<\/i> subsp. <i>griseus<\/i>"],"prefix":"10.1139","volume":"62","author":[{"given":"Yulian","family":"Zhan","sequence":"first","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, People\u2019s Republic of China."},{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaolun","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, People\u2019s Republic of China."},{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010573427080"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00330a045"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb18973.x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1021\/cr970113"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.3390\/s120911922"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1039\/C39940002287"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1039\/A804284E"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(02)00598-8"},{"key":"refg9\/ref9","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/hlca.19750580718","volume":"58","author":"Gerlach H.","year":"1975","journal-title":"Helv. 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