{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:17:18Z","timestamp":1792984638115,"version":"4.5.0"},"reference-count":44,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> The emergence of multidrug-resistant bacteria demands innovations in the development of new antibiotics. For decades, the glycopeptide antibiotic vancomycin has been considered as the \u201clast resort\u201d treatment of severe infections caused by Gram-positive bacteria. Since the discovery of the first vancomycin-resistant enterococci strains in the late 1980s, the number of resistances has been steadily rising, with often life-threatening consequences. As an alternative to the generation of completely new substances, novel approaches focus on structural modifications of established antibiotics such as vancomycin to overcome these resistances. Here, we provide an overview of several promising modifications of vancomycin to restore its efficacy against vancomycin-resistant enterococci. <\/jats:p>","DOI":"10.1139\/cjm-2019-0309","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T21:34:51Z","timestamp":1569274491000},"page":"11-16","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":142,"title":["Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria"],"prefix":"10.1139","volume":"66","author":[{"given":"Eric","family":"M\u00fchlberg","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Umst\u00e4tter","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kleist","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Domhan","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Mier","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Uhl","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.150976"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S173867"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1086\/587654"},{"issue":"8","key":"refg4\/ref4","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1128\/JCM.36.8.2187-2190.1998","volume":"36","author":"Bell J.M.","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/246012"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02123-w"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.7.3.311"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30605-4"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1111\/eva.12185"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0931492100"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01250.x"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1086\/491711"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-011-9868-6"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2572"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-6234-5"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201902210"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.07.003"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00473-0"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.16.020916"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.3201\/eid0402.980211"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.3.280"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.9.1904"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt302"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1086\/491709"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2000.tb01517.x"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-005-0408-9"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1086\/520283"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000539"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80270-8"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704125114"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047297"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1086\/381972"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.14.9210"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02250-16"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142284"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2006.02.005"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.2174\/1389557516666160907151454"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020232"},{"key":"refg39\/ref39","unstructured":"Steinhilber, D., Schubert-Zsilavecz, M., and Roth, H.J. 2010. Medizinische Chemie: Targets - Arzneistoffe - chemische Biologie. 2., v\u00f6llig neu bearbeitete und erweiterte Auflage. Deutscher Apotheker-Verlag, Stuttgart."},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.04.004"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.07.013"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5413.442"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1021\/jm500270w"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201601621"}],"container-title":["Canadian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjm-2019-0309","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjm-2019-0309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:50:25Z","timestamp":1751478625000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjm-2019-0309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1139\/cjm-2019-0309"],"URL":"https:\/\/doi.org\/10.1139\/cjm-2019-0309","relation":{},"ISSN":["0008-4166","1480-3275"],"issn-type":[{"value":"0008-4166","type":"print"},{"value":"1480-3275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}