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In recent years, several studies have reported an increase in the recovery rates of azole-resistant C. tropicalis isolates. Understanding C. tropicalis resistance is of great importance, since resistant strains are implicated in persistent or recurrent and breakthrough infections. In this review, we address the main mechanisms underlying C. tropicalis resistance to the major antifungal classes used to treat candidiasis. The main genetic basis involved in C. tropicalis antifungal resistance is discussed. A better understanding of the epidemiology of resistant strains and the mechanisms involved in C. tropicalis resistance can help improve diagnosis and assessment of the antifungal susceptibility of this Candida species to improve clinical management. <\/jats:p>","DOI":"10.1139\/cjm-2019-0531","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T12:29:42Z","timestamp":1587558582000},"page":"377-388","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["The yeast, the antifungal, and the wardrobe: a journey into antifungal resistance mechanisms of <i>Candida tropicalis<\/i>"],"prefix":"10.1139","volume":"66","author":[{"given":"Jonathas Sales de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Graduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza-CE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandbergue Santos","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Graduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza-CE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora de Souza Collares Maia","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Graduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza-CE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana de Aguiar","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Graduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza-CE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 J\u00falio Costa","family":"Sidrim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Graduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza-CE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimunda S\u00e2mia Nogueira","family":"Brilhante","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Graduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza-CE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos F\u00e1bio Gadelha","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Graduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza-CE, Brazil."},{"name":"School of Veterinary, Postgraduate Program in Veterinary Sciences, State University of Cear\u00e1, 1315 Coronel Nunes de Melo Street, Rodolfo Te\u00f3filo, CEP 60420-270, Fortaleza-CE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit136"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2017.04.005"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2016.02.001"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000072448"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2016.06.029"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","unstructured":"Arastehfar, A., Daneshnia, F., Hafez, A., Khodavaisy, S., Najafzadeh, M.J., Charsizadeh, A. et al. 2019. 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