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J. Microbiol."],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p> Fungal resistance to available antifungal molecules has emerged as a significant and continued threat. Several plants, including cannabis, have promising antimicrobial activities, potentially including those against C andida albicans. Thus, this study aimed to evaluate the antifungal activities of cannabidiol (CBD) against C. albicans. Yeast cells were treated once or twice with different concentrations (from 0 to 20 \u00b5g\/mL) of CBD, showing a significant ( p\u00a0&lt;\u00a00.05) decrease of the growth of C. albicans, with cell concentrations ranging from 5.1\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> cells\/mL in the control to 1.8\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> cells\/mL after one exposure to 20 \u00b5g\/mL CBD. This growth reduction was greater after two exposures to CBD. After two exposures to 20 \u00b5g\/mL CBD, the cell concentration was only 1.1\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> cells\/mL. Such a growth decrease in C. albicans was confirmed by a reduced number of colony forming units and a lower MTT value compared to the control. The growth inhibition was supported by a significant ( p\u00a0&lt;\u00a00.001) decrease in the yeast-to-hyphae transition, ranging from 20 \u00b1 0.2% in the control to 2 \u00b1 0.5% after exposure to 20 \u00b5g\/mL CBD. Biofilm formation was also significantly reduced following CBD exposure. CBD at 10 and 20 \u00b5g\/mL promoted the death of C. albicans through an apoptosis\/necrotic pathway. Altogether, our results suggest the possible use of CBD, a cannabis derivative, to control C. albicans infection, including oral candidiasis. <\/jats:p><jats:sec><jats:title>Highlights<\/jats:title><jats:p> Cannabidiol (CBD) decreases the growth of C. albicans. CBD inhibits the yeast-to-hyphae transition. CBD reduces biofilm formation by C. albicans. CBD induces C. albicans death through necrosis. <\/jats:p><\/jats:sec>","DOI":"10.1139\/cjm-2024-0034","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T21:35:36Z","timestamp":1729200936000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of cannabidiol (CBD), a cannabis plant derivative, against <i>Candida albicans<\/i> growth and biofilm formation"],"prefix":"10.1139","volume":"71","author":[{"given":"Maryam","family":"Bahraminia","sequence":"first","affiliation":[{"name":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire Universit\u00e9 Laval","place":["Quebec City, Canada"]},{"name":"Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval","place":["Quebec City, Canada"]},{"name":"Universit\u00e9 Laval","place":["Quebec City, 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